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Familial diabetes mellitus in Samoyed dogs
Diabetes mellitus is a common disease in middle aged and older dogs. Not too much is known about a genetic background. In this study, five closely related Samoyed dogs developed this disease suggesting that there might be a familial predisposition of diabetes mellitus at least in this breed.

Five adult Samoyed dogs from two unrelated litters were diagnosed with diabetes mellitus.

Two full-sibling male dogs (Family A) were raised in the same household.

The other three dogs, two female and one male, were also full siblings (Family B) raised in different households.

All five dogs developed polyuria and polydipsia and demonstrated fasting hyperglycemia and glucosuria.

Diabetes mellitus was diagnosed in all five dogs and responded to appropriate therapy with insulin.

The occurrence of insulin-dependent diabetes mellitus in multiple, closely related Samoyed dogs suggests a familial predisposition in this breed.


Source: Susan E. Kimmel, Cynthia R. Ward, Paula S. Henthorn, Rebecka S. Hess (2002): Familial Insulin-Dependent Diabetes Mellitus in Samoyed Dogs. In: Journal of the American Animal Hospital Association 38:235-238 (2002)



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SMALL ANIMAL PRACTICE

Variability of SDMA in apparently healthy dogsmembers
Symmetric dimethylarginine (SDMA) is a screening tool for early kidney dysfunction and monitoring treatment in cases of chronic kidney disease (CKD). There are no current studies describing the suitability of this test for use with published population‐based reference intervals. The objectives of this study were to determine the components of biological variability, the index of individuality (IOI), the critical difference between sequential measurements (CD) and the number of measurements required to assess the homeostatic set point (HSP), for both SDMA and serum creatinine (sCr), in apparently healthy dogs.

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