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Familial diabetes mellitus in Samoyed dogs
Diabetes mellitus is a common disease in middle aged and older dogs. Not too much is known about a genetic background. In this study, five closely related Samoyed dogs developed this disease suggesting that there might be a familial predisposition of diabetes mellitus at least in this breed.

Five adult Samoyed dogs from two unrelated litters were diagnosed with diabetes mellitus.

Two full-sibling male dogs (Family A) were raised in the same household.

The other three dogs, two female and one male, were also full siblings (Family B) raised in different households.

All five dogs developed polyuria and polydipsia and demonstrated fasting hyperglycemia and glucosuria.

Diabetes mellitus was diagnosed in all five dogs and responded to appropriate therapy with insulin.

The occurrence of insulin-dependent diabetes mellitus in multiple, closely related Samoyed dogs suggests a familial predisposition in this breed.


Source: Susan E. Kimmel, Cynthia R. Ward, Paula S. Henthorn, Rebecka S. Hess (2002): Familial Insulin-Dependent Diabetes Mellitus in Samoyed Dogs. In: Journal of the American Animal Hospital Association 38:235-238 (2002)



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SMALL ANIMAL PRACTICE

Radioactive iodine uptake in hyperthyroid cats after rh-TSHmembers
Radioactive iodine therapy is considered the treatment of choice for hyperthyroidism in cats, but the availability of this modality is limited by costs and hospitalization requirements. Administration of recombinant human thyroid stimulating hormone (rh‐TSH) to humans with thyroid neoplasia or nodular goiter can increase thyroidal iodine uptake, thereby allowing the use of lower radioactive iodine doses for treatment. Veterinary studies of this subject are limited, and results are conflicting. Thus, the objective of this study was to investigate the effects of rh‐TSH administration on thyroidal iodine uptake in hyperthyroid cats.

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