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Four Fraction Palliative Radiotherapy for Canine Osteosarcoma
Osteosarcomas are highly malignant neoplasias affecting especially middle aged dogs of large or giant breeds. Once diagnosed, the prognosis is guarded. Is the four fraction palliative radiotherapy offering favourable prognoses in those cases? The results of this study show that it might be effective for the palliation of clinical signs and prolong the survival time a little.

Twenty-four dogs underwent palliative radiotherapy consisting of four 8 gray (Gy) fractions of 60Co radiation on days 0, 7, 14, and 21 at 26 sites for axial (n=11) or appendicular (n=15) osteosarcoma.

Response was noted in 92% of sites treated.

Seventeen dogs were euthanized due to local or metastatic disease, one dog died of metastatic disease, five dogs died of unrelated causes, and one dog is alive.

The four fraction protocol is effective for palliation of clinical signs associated with axial or appendicular osteosarcoma and may result in a higher response rate and longer survival time than three fraction palliative protocols.


Source: Eric M. Green, William M. Adams, Lisa J. Forrest (2002): Four Fraction Palliative Radiotherapy for Osteosarcoma in 24 Dogs. In: Journal of the American Animal Hospital Association 38:445-451 (2002)



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SMALL ANIMAL PRACTICE

Variability of SDMA in apparently healthy dogsmembers
Symmetric dimethylarginine (SDMA) is a screening tool for early kidney dysfunction and monitoring treatment in cases of chronic kidney disease (CKD). There are no current studies describing the suitability of this test for use with published population‐based reference intervals. The objectives of this study were to determine the components of biological variability, the index of individuality (IOI), the critical difference between sequential measurements (CD) and the number of measurements required to assess the homeostatic set point (HSP), for both SDMA and serum creatinine (sCr), in apparently healthy dogs.

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  • Enterococcus faecium SF68 on serum cobalamin and folate concentrationsmembers
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  • Staining hair samples with a modified Wright-Giemsa stain to diagnose feline dermatophytosismembers
  • Oral extended release hydrocodone as analgesia after TPLOmembers
  • 25OH vitamin D3 serum concentration in dogs with acute polyradiculoneuritismembers
  • Type 1 immune mediated polyarthritis in dogs and temporal relationship to vaccination members


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