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Clindamycin once daily in canine pyoderma
The treatment of canine pyoderma with `staphylococcal-effective` antibiotics can become very expensive, especially if large dogs need to be treated over weeks. Is clindamycin given only once daily an effective therapeutic option? Might be!

Twenty-one dogs with canine superficial bacterial pyoderma were treated with clindamycin at a dosage of approximately 11 mg/kg body weight, q 24 hours, given orally for 14 to 42 days.

All dogs were reexamined on days 14, 28, and, if necessary, 42 and given a clinical score of excellent (i.e., complete remission), good (i.e., primary lesions resolved but secondary lesions evident), fair (i.e., partial improvement but primary lesions still evident), or poor (i.e., no improvement or worsening of the lesions).

A clinical score of excellent was obtained in 71.4% (15/21) of the dogs in this study within 14 to 28 days.


Source: PB Bloom and EJ Rosser (2001): Efficacy of once-daily clindamycin hydrochloride in the treatment of superficial bacterial pyoderma in dogs. In: Journal of the American Animal Hospital Association, Vol 37, Issue 6, 537-542



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SMALL ANIMAL PRACTICE

Variability of SDMA in apparently healthy dogsmembers
Symmetric dimethylarginine (SDMA) is a screening tool for early kidney dysfunction and monitoring treatment in cases of chronic kidney disease (CKD). There are no current studies describing the suitability of this test for use with published population‐based reference intervals. The objectives of this study were to determine the components of biological variability, the index of individuality (IOI), the critical difference between sequential measurements (CD) and the number of measurements required to assess the homeostatic set point (HSP), for both SDMA and serum creatinine (sCr), in apparently healthy dogs.

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