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Biochemical abnormalities in cartilage of dogs with OCD
OCD (osteochondrosis dissecans) is a common problem especially of young dogs of large or giant breeds. Which changes are characteristic for the affected cartilage? An American study group found a couple of them, most impressive is the significant lower glycosaminoglycan concentration and another collagen composition - reason or sequela of the OCD?

This study was performed to determine glycosaminoglycan (GAG) concentration and immunohistochemical staining characteristics of type-I, -II, and -X collagen from cartilage affected by osteochondritis dissecans (OCD) in dogs.

31 dogs with OCD and 11 clinically normal purpose-bred dogs were included.

Cartilage samples were evaluated microscopically, and GAG content was determined. Immunohistochemical staining was performed for type-I, -II, and -X collagen. Sections were subjectively evaluated for location and intensity of staining.

Results: Cartilage affected by OCD had a variety of pathologic changes and significantly lower GAG concentrations than did normal cartilage. Normal cartilage had no detectable type-I collagen.

For dogs < 9 months of age, cartilage affected by OCD had significantly more type-I collagen but significantly less type-X collagen than did control cartilage. For dogs > 12 months of age, cartilage affected by OCD contained significantly more type-I collagen than did control cartilage.

There was a significant negative correlation between immunoreactivity of type-I collagen and that of type-II and -X collagen.

A significant positive correlation was found between immunoreactivity of type-II and -X collagen.

Thus, cartilage affected by OCD contains less GAG, more type-I collagen, and less type-X collagen, compared with normal cartilage. A direct correlation between these changes and the etiopathogenesis of OCD was not established.


Source: Tomlinson JL, Cook JL, Kuroki K, Kreeger JM, Anderson MA. (2001): Biochemical characterization of cartilage affected by osteochondritis dissecans in the humeral head of dogs. In: Am J Vet Res. 2001 Jun;62(6):876-81.



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