|Biochemical abnormalities in cartilage of dogs with OCD
OCD (osteochondrosis dissecans) is a common problem especially of young dogs of large or giant breeds. Which changes are characteristic for the affected cartilage? An American study group found a couple of them, most impressive is the significant lower glycosaminoglycan concentration and another collagen composition - reason or sequela of the OCD?|
|This study was performed to determine glycosaminoglycan (GAG) concentration and immunohistochemical staining characteristics of type-I, -II, and -X collagen from cartilage affected by osteochondritis dissecans (OCD) in dogs.
31 dogs with OCD and 11 clinically normal purpose-bred dogs were included.
Cartilage samples were evaluated microscopically, and GAG content was determined. Immunohistochemical staining was performed for type-I, -II, and -X collagen. Sections were subjectively evaluated for location and intensity of staining.
Results: Cartilage affected by OCD had a variety of pathologic changes and significantly lower GAG concentrations than did normal cartilage. Normal cartilage had no detectable type-I collagen.
For dogs < 9 months of age, cartilage affected by OCD had significantly more type-I collagen but significantly less type-X collagen than did control cartilage. For dogs > 12 months of age, cartilage affected by OCD contained significantly more type-I collagen than did control cartilage.
There was a significant negative correlation between immunoreactivity of type-I collagen and that of type-II and -X collagen.
A significant positive correlation was found between immunoreactivity of type-II and -X collagen.
Thus, cartilage affected by OCD contains less GAG, more type-I collagen, and less type-X collagen, compared with normal cartilage. A direct correlation between these changes and the etiopathogenesis of OCD was not established.
Source: Tomlinson JL, Cook JL, Kuroki K, Kreeger JM, Anderson MA. (2001): Biochemical characterization of cartilage affected by osteochondritis dissecans in the humeral head of dogs. In: Am J Vet Res. 2001 Jun;62(6):876-81.
Tell a friend
Send this article
Metastasis of a well differentiated perianal gland tumorPunica granatum associated with hepatotoxicosis in cattleToceranib phosphate (PalladiaÂ®) in canine gastrointestinal stromal tumorsRadioactive iodine uptake in hyperthyroid cats after rh-TSHHypoechoic tissue changes in dogs with malignant prostatic lymphomaEmphysematous gastritis in dogs and catsPrimary pulmonary histiocytic sarcoma in dogsDetermining prognosis in canine sepsis Correlation of plasma and tear glucose, creatinine and urea nitrogen in catsPerineal hernias in dogs - always a bilateral problem?Pharmacokinetic of gabapentin in catsFollicular development of canine ovaries stimulated by eCG plus hCG