Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Topical pimecrolimus in canine KCS
Keratoconjuctivitis sicca (KCS) is a common eye disease in certain breeds. The most popular current therapy consists is the application of a topical cyclosporin A-preparation. In dermatology, other cyclosporin-relatives like tacrolimus or pimecrolimus are used topically for months or even years with good results. Is pimecrolimus also a new alternative in the eye?

Pimecrolimus is an ascomycin derivative that interferes selectively with the activation of T cells and mast cells and inhibits the production of inflammatory cytokines.

This study evaluated the efficacy of an experimental ophthalmic formulation of pimecrolimus in treating keratoconjunctivitis sicca (KCS) and chronic superficial keratitis (CSK) in dogs.

Eight dogs with KCS and six with CSK were included. The dogs were of various breeds, suffered from chronic conditions, and had been pretreated unsuccessfully. The affected eyes were treated with 1 drop of an experimental, corn oil-based pimecrolimus 1% formulation three times a day.

Parameters evaluated included Schirmer tear test (STT), ocular discharge, conjunctival inflammation, corneal inflammatory cell infiltrate and scarring, and comfort level.

Results: The effect of pimecrolimus 1% was pronounced (increase in STT values to higher than 4 mm/min, no signs of inflammation) or moderate (increase in STT values of 34 mm/min, mild signs of corneal/conjunctival inflammation) in a total of 6/8 animals with KCS.

In 4/6 animals with CSK, the effect was either pronounced (total regression of fibrovascular infiltration into the cornea, no corneal scarring) or moderate (distinct regression of pannus, mild corneal scarring).

The response to treatment was unsatisfactory in four of 14 animals.

Results of this exploratory study suggest that topical 1% pimecrolimus may be a new effective treatment for keratoconjunctivitis sicca and chronic superficial keratitis in dogs.



Source: Nell, Barbara, Walde, Ingo, Billich, Andreas, Vit, Peter & Meingassner, Josef G. (2005): The effect of topical pimecrolimus on keratoconjunctivitis sicca and chronic superficial keratitis in dogs: results from an exploratory study. In: Veterinary Ophthalmology 8 (1), 39-46.




Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Oral extended release hydrocodone as analgesia after TPLOmembers
Tibial plateau leveling osteotomy (TPLO) is a very popular technique to treat ruptured cranial cruciate ligaments in dogs, and it requires a balanced analgesia regimen after surgery. The aim of this study was to determine the efficacy of oral extended‐release hydrocodone compared with oral firocoxib for analgesia following tibial plateau leveling osteotomy surgery in dogs in a hospital setting.

  • 25OH vitamin D3 serum concentration in dogs with acute polyradiculoneuritismembers
  • Type 1 immune mediated polyarthritis in dogs and temporal relationship to vaccination members
  • Phosphorus and protein supply before diagnosis of chronic kidney disease members
  • Bilateral retinoschisis in a Labrador retrievermembers
  • Water requirements of canine athletes during exercise over daysmembers
  • Predictors of Sudden Cardiac Death in Doberman Pinschers with DCMmembers
  • D-dimer concentration after soft tissue and orthopedic surgery members
  • Canine oral mucosa as autograft in unresponsive keratoconjunctivitis siccamembers
  • Computed tomographic findings in dogs infected with Crenosoma vulpismembers
  • Predicting histopathological classification of canine mammary carcinomas via sonographymembers
  • The expression of Vitamin D receptors in dogsmembers
  • Complex atlanto-axial malformation in a rabbitmembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved