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Diltiazem once daily in cats with hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy is not too rare in cats and its therapy is often difficult because many cat owners are not able to give medication several times a day. How good is an extended-released diltiazem therapy which needs to be given only once a day?

Serum diltiazem concentrations were evaluated following either 30 mg or 60 mg of an extended-release diltiazem administered orally once daily to 13 cats.

Sequential blood samples were obtained over 24 hours. Both dosages usually resulted in elevated serum concentrations of >200 ng/mL at 6, 12, 18, and 24 hours.

The 30-mg dosage was sometimes associated with low serum concentrations of <50 ng/mL at 18 and 24 hours.
The 60-mg dosage (9.3 to 14.8 mg/kg) was associated with lethargy, gastrointestinal disturbances, and weight loss in nine (36%) of 25 client-owned cats.

Gastrointestinal disturbances were recognized within 1 week, and weight loss was detected after 2 to 6 months of treatment.

Source: Michelle Wall, Clay A. Calvert, Sherry L. Sanderson, Andrea Leonhardt, Corrie Barker, Tiffany K. Fallaw (2005): Evaluation of Extended-Release Diltiazem Once Daily for Cats With Hypertrophic Cardiomyopathy. In: Journal of the American Animal Hospital Association 41:98-103 (2005)




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SMALL ANIMAL PRACTICE

Storage temperatures and container types and the urine protein : creatinine ratios
Preanalytic protein adsorption to polymer and glass container surfaces may decrease urine protein concentration measurements and urine protein: creatinine ratios (UPC). Does urine stored in PC or glass containers have lower UPC than urine stored in HP containers? The specific objective was to determine whether clinically relevant differences in UPC would be detected after storage in glass, PC, or HP containers using common storage times and temperatures. Twelve client‐owned dogs with proteinuria helped to answer these important questions.

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