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Results of surgical excision of vaccine-induced fibrosarcomas in cats
Vaccinations are performed to protect the animal from various infectious diseases. A lot of discussions have been raised because there is a risk to create malignant neoplasia with the subcutaneous vaccine application in some cats. Is surgery the therapy of choice once such a neoplasia is diagnosed?

This retrospective study has been undertaken to evaluate time to first recurrence (TFR) and overall survival in cats with presumed vaccine-associated sarcomas (VAS) treated with excision. 61 cats with presumed VAS were included.

Medical records of cats that received excision as the only initial treatment for presumed VAS were reviewed to evaluate prognosis. Overall survival curves and TFR were determined.

RESULTS: Median TFR was 94 days. Median TFR for tumors treated with excision performed at a referral institution (274 days) was significantly longer than that for tumors excised by a referring veterinarian (66 days).

Radical first excision yielded significantly longer median TFR (325 days) than did marginal first excision (79 days).

Cats with tumors located on the limbs had longer median TFR (325 days) than cats with tumors located in other sites (66 days).

Median overall survival time was 576 days. Significant differences in survival times between groups were not detected. Few cats (13.8%) receiving only surgical treatment had long-term (> 2 years) survival.

Thus, radical first excision of presumed VAS is essential for extended TFR.

Current recommendations for vaccination of the distal portions of the extremities are appropriate, because this practice permits radical excision of tumors (amputation) that develop at vaccination sites; however, surgery alone is seldom curative.


Source: Hershey AE, Sorenmo KU, Hendrick MJ, Shofer FS, Vail DM (2000): Prognosis for presumed feline vaccine-associated sarcoma after excision: 61 cases (1986-1996). In: J Am Vet Med Assoc. 2000 Jan 1;216(1):58-61.




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