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Sex reversal syndrome in a mare
Mares behaving like stallions are sometimes seen in veterinary practice. They often cause problems in handling, riding and so on. In this case report, an unusual diagnosis in such a mare finally could be made: She had hormonal problems, called testicular feminization syndrome!

A 5-year-old Thoroughbred mare was subjected to cytogenetic and molecular analysis because of infertility and masculine behaviour. Chromosome studies, including painting with the whole X chromosome specific probe, revealed a male chromosome complement (64,XY).

The PCR amplification of the SRY and ZFY genes showed the presence of both those genes, while the endocrinological study demonstrated a high level of testosterone (9.7 nmol/l).

Sequencing of the SRY gene (1121 bp), comprising also 5`- and 3`-UTRs, did not reveal any differences when compared with the sequence of normal stallions.

It was proposed that this mare represents the androgen insensitivity syndrome (testicular feminization syndrome).



Source: Switonski, M., Chmurzynska, A., Szczerbal, I., Lipczynski, A., Yang, F. & Nowicka-Posuszna, A. (2005): Sex reversal syndrome (64,XY; SRY-positive) in a mare demonstrating masculine behaviour. In: Journal of Animal Breeding and Genetics 122 (s1), 60-63.




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EQUINE

Septic keratitis - associated bacteria and antibiotic susceptibilitymembers
Septic keratitis is occasionally seen in various species. The aim of this study was to evaluate the most common bacterial pathogens associated with septic keratitis in veterinary patients from Switzerland. The second objective was to analyze antibiotic susceptibility test results of the identified bacterial pathogens. The third objective was to evaluate potential breed predispositions to septic keratitis. A very interesting study with results not only important for Switzerland!

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