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Cutaneous neosporosis in a dog with pemphigus foliaceus
Pemphigus foliaceus is one of the most common autoimmune diseases in dogs. Its therapy consists of immunosuppressive drugs, the therapy of choice is the combination of prednisolone and azathioprine. It is well known that this therapy can also reduce the cutaneous immune systeme and favour infections with dermatophytes. But also with organisms like neospora, at least in certain climates, as this case report from Spain documents.

A 4-year-old, intact male rottweiler was presented with a 10-day history of papulonodular dermatitis.

At the time of presentation, the dog was receiving prednisone and azathioprine to treat pemphigus foliaceus.

Cutaneous neosporosis was diagnosed by immunohistochemistry on skin biopsy specimens and a high serum antibody titer to Neospora caninum by Neospora agglutination test.

Electron microscopy examination of skin specimens further supported the diagnosis.

Clindamycin therapy, together with withdrawal of immunosuppressive medication, resulted in prolonged clinical remission.

This report documents cutaneous neosporosis in an adult dog and suggests that immunosuppressive therapy might be a predisposing factor.




Source: Laura Ordeix, Albert Lloret, Dolors Fondevila, J. P. Dubey, Lluís Ferrer, Alessandra Fondati (2002): Cutaneous Neosporosis During Treatment of Pemphigus Foliaceus in a Dog. In: Journal of the American Animal Hospital Association 38:415-419 (2002)



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SMALL ANIMAL PRACTICE

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