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Piroxicam and carboplatin in canine oral non-tonsillar squamous cell carcinoma
Squamous cell carcinomas of the oral mucosa are known to be very aggressive and often very frustrating in their therapy. Does this combination of carboplatin and piroxicam coming from human medicine offer better therapeutic results than the current therapies? At least the preliminary results seems to be promising!

Results of the treatment with a combination of carboplatin and piroxicam in seven dogs with advanced non-tonsillar oral squamous cell carcinoma (SCC) were retrospectively analysed.

This multi-agent protocol was well tolerated by all dogs and resulted in a complete regression of the tumour without additional surgery in four of seven patients.
Additional surgery was necessary to remove a metastatic lymph node in one dog and residual tumour in a second dog, which achieved a partial response following medical therapy.

Median follow-up for all the dogs was 534 days, while the time-to-recurrence, time-to-progression and overall survival for this group of patients have not yet been reached.

Our study, although limited in number of animals, suggests that this multiagent approach is a useful treatment option for oral non-tonsillar SCC in dogs and warrants wider application.



Source: de Vos, J. P., Burm, A. G. D., Focker, A. P., Boschloo, H., Karsijns, M. & van der Waal, I. (2005): Piroxicam and carboplatin as a combination treatment of canine oral non-tonsillar squamous cell carcinoma: a pilot study and a literature review of a canine model of human head and neck squamous cell carcinoma. In: Veterinary and Comparative Oncology 3 (1), 16-24.




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SMALL ANIMAL PRACTICE

Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a Rat terrier
A female neutered Rat Terrier was presented for an acute onset of seizure‐like episodes, weakness, and vomiting approximately 14 hours after ingestion of 198 mg/kg of metformin. The dog was found to be laterally recumbent, paddling, and unresponsive shortly before presentation. On physical exam, the dog was in hypovolemic shock and hypothermic. It was finally diagnosed as severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. This case report describes diagnosis and therapy.

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