Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Piroxicam and carboplatin in canine oral non-tonsillar squamous cell carcinoma
Squamous cell carcinomas of the oral mucosa are known to be very aggressive and often very frustrating in their therapy. Does this combination of carboplatin and piroxicam coming from human medicine offer better therapeutic results than the current therapies? At least the preliminary results seems to be promising!

Results of the treatment with a combination of carboplatin and piroxicam in seven dogs with advanced non-tonsillar oral squamous cell carcinoma (SCC) were retrospectively analysed.

This multi-agent protocol was well tolerated by all dogs and resulted in a complete regression of the tumour without additional surgery in four of seven patients.
Additional surgery was necessary to remove a metastatic lymph node in one dog and residual tumour in a second dog, which achieved a partial response following medical therapy.

Median follow-up for all the dogs was 534 days, while the time-to-recurrence, time-to-progression and overall survival for this group of patients have not yet been reached.

Our study, although limited in number of animals, suggests that this multiagent approach is a useful treatment option for oral non-tonsillar SCC in dogs and warrants wider application.



Source: de Vos, J. P., Burm, A. G. D., Focker, A. P., Boschloo, H., Karsijns, M. & van der Waal, I. (2005): Piroxicam and carboplatin as a combination treatment of canine oral non-tonsillar squamous cell carcinoma: a pilot study and a literature review of a canine model of human head and neck squamous cell carcinoma. In: Veterinary and Comparative Oncology 3 (1), 16-24.




Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Diagnostic Markers in Dogs With Hemangiosarcoma Related Hemoabdomen
Hemoabdomen as a consequence of a ruptured hemangiosarcoma especially in splen or liver is a common emergency in small animal practice. Not in all cases sonography is available to diagnose this causative neoplasia. This recently published new study investigates: 1) acanthocytosis and presence of acanthocytes in peritoneal fluid as a diagnostic marker for hemangiosarcoma (HSA) in dogs with non-traumatic hemoabdomen; and 2) the association between other erythrocyte, biochemical, and hematologic abnormalities as a mean of differentiating HSA from other disease.
Very relevant for daily practice!

  • Regional Lymph Node Metastatic Burden and Prognosis in Canine Malignant Mammary Tumors members
  • Enhancing bleomycin efficacy in cats with periocular carcinoma and advanced SCC of the headmembers
  • LGI Proteins and Epilepsy in Animals and Humansmembers
  • Iodine-Restricted Diet in Cats with Spontaneous Hyperthyroidismmembers
  • Coagulation abnormalities in cats with naturally occurring cytauxzoonosismembers
  • Acute transfusion reactions in dogs and the effect of premedicationmembers
  • 3D-CRT in dogs with massive hepatocellular carcinoma
  • In vivo confocal microscopy for diagnosis and therapy control of canine fungal keratitis members
  • S-Measurement in the Diagnosis of Canine Hip Dysplasiamembers
  • Concentrations of a marker of type I collagen metabolism in ragdolls with HCMmembers
  • Novel surgical technique for perineal hernia repairmembers
  • Prognostic indicators in dogs with head traumamembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2013 VetContact GmbH
    All rights reserved