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Do dogs with gastric dilatation benefit from metoclopramide therapy?
Gastric dilatation-volvulus (GDV) is a disorder characterized by delayed gastric emptying. Is metoclopramide, a putative gastroprokinetic agent, a `must have` for dogs that had recovered from GDV? An interesting an very important question in every day-practice!

6 healthy dogs and 5 dogs after treatment and recovery from GDV were included in this study.

Baseline recordings of gastric electrical and contractile activities were made 8 or 10 days after circumcostal gastropexy and implantation of serosal electrodes and strain-gauge force transducers.

Gastric activities were recorded again the next day after treatment with the clinically recommended oral metoclopramide dose (0.3 mg/kg of body weight) administered a half hour before feeding.

Recordings were analyzed to determine gastric slow-wave frequency, presence of slow-wave dysrhythmia, slow-wave propagation velocity, coupling of contractions to slow waves, a motility index based on relative contractile amplitudes, and onset of contractions after a standardized meal.

RESULTS: Significant differences in gastric electrical or contractile activities were not detected after metoclopramide treatment in dogs with GDV. Compared with control dogs after metoclopramide treatment, gastric slow-wave propagation velocity was significantly (P = 0.03) faster for the dogs with GDV at postprandial minute 90.

CONCLUSION: At a clinically recommended dosage, metoclopramide treatment did not change gastric myoelectric and motor activities in a way that would promote increased gastric emptying in dogs with GDV.

CLINICAL RELEVANCE: Metoclopramide treatment may not benefit dogs with GDV and delayed gastric emptying.

Source: Hall JA, Solie TN, Seim HB 3rd, Twedt DC (1996): Effect of metoclopramide on fed-state gastric myoelectric and motor activity in dogs. In: Am J Vet Res. 1996 Nov;57(11):1616-22



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