Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Privacy Policy  
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Equine /     
 
l-Bupivacaine 0.5% or racemic 0.5% bupivacaine for caudal epidural analgesia in horses?
Bupivacaine is a well established substance used for caudal epidural anesthesia in several species, also in horses. Are there differences between different kinds of bupivacaine regarding efficacy and duration of analgesia? A very important question which is followed in this brandnew well-designed study!

Bupivacaine is available as a racemic mixture of its enantiomers, d-bupivacaine and l-bupivacaine (LB).

The aim of this randomized, double-blind study was to investigate the clinical efficacy and safety of S()-bupivacaine compared with standard racemic bupivacaine (RB) in horses under caudal epidural analgesia.

Two treatments were administered to each horse, with a 2-week interval between subsequent treatments.

Treatment 1 consisted of 0.5% LB at a dose of 0.06 mg/kg of body weight, and treatment 2 consisted of 0.5% RB at a dose of 0.06 mg/kg of body weight.

Epidural injections were given in all animals between the first and second coccygeal vertebra. Heart rate (HR), arterial pressures, respiratory rate (RR), rectal temperature (RT), analgesia, and motor blocking were determined before drug administration (basal) and 5, 10, 15 and 30 min after drug administration, and at 30 min intervals thereafter.

There were no significant differences between the two treatments in the quality of sensory and motor block.

The duration of analgesia was 320 ± 30 min (mean ± SD) for RB and 360 ± 42 min for LB. HRs and RRs, arterial pressures and RT did not change (P < 0.05) significantly from basal values after epidural administration of LB or RB.

This study supports that 0.5% LB is an effective alternative to RB in caudal epidural analgesia in conscious, standing horses. The use of LB vs. RB warrants further investigation, particularly for long-lasting surgery in the perineal region.



Source: DEROSSI, R., MIGUEL, G. L. S., FRAZÍLIO, F. O., NUNES, D. B. & KASSAB, T. A. (2005): l-Bupivacaine 0.5% vs. racemic 0.5% bupivacaine for caudal epidural analgesia in horses. In: Journal of Veterinary Pharmacology & Therapeutics 28 (3), 293-297.




Tell a friend   |   Print version   |   Send this article

EQUINE

The farrier role in supporting horse owners to prevent laminitismembers
Emerging research highlights how, due to demographic changes in horse owner populations in Western societies, complex owner–horse relationships are leading to inappropriate horse care, including overnutrition, which in turn can lead to laminitis. Farriers, due to their regular visits, may be in a position to support owners in dealing with this problem. This study explored whether UK farriers have a role in working with horse owners to support horse welfare and prevent laminitis.

  • CT description of equine oromaxillary sinus and oronasal fistulaemembers
  • Insulin and the structural integrity of equine digital lamellaemembers
  • Exercise-induced pulmonary haemorrhage in Thoroughbred racehorsesmembers
  • Specific bioactive collagen peptides (PETAGILE®) in horses with osteoarthritismembers
  • Epidural anaesthesia in horses with perineal and tail melanomasmembers
  • Unexpected cause of haematuria in an Egyptian Arabian stallionmembers
  • First description of hypersplenism in an old miniature ponymembers
  • Endocrinopathies associated with severe hypertriglyceridaemia in horses and poniesmembers
  • Clinical effect of corticosteroids in horses with asthmamembers
  • Severe complications of cheek tooth extraction in a ponymembers
  • Septic keratitis - associated bacteria and antibiotic susceptibilitymembers
  • Traumatic coccygeal luxation and distal amputation of the tail of a horsemembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved