Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
  Interferon  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Aqueous tacrolimus solution in canine KCS
Keratoconjunctivitis sicca (KCS) is a common problem in certain dog breeds. Years ago the only effective therapy was the subconjunctival injection of corticosteroids followed by topical steroids combined with artificial tears, and the discovery of cyclosporin A offered a very important and effective alternative in the therapy of this chronic eye problems. How effective is tacrolimus, which acts similar to cyclosporin A and is used a lot now in canine medicine?

One hundred five dogs diagnosed with KCS [Schirmer tear test (STT) 10 mm/min and clinical signs of dry eye] were included in this study. Eyes with marginally decreased STT (11 15 mm/min) and clinical signs of dry eye were also evaluated.

The investigation was conducted in two parts: an initial efficacy study and a subsequent double blinded controlled study.

In the efficacy study, the effect of topical tacrolimus (formerly FK-506) on tear production in dogs with primary KCS was evaluated.

Dogs were divided into four categories: 1) 59 eyes (38 dogs) naïve to tear stimulation therapy with initial STT 10 mm/min; 2) 28 eyes (21 dogs) naïve to tear stimulation therapy with initial STT 11 15 mm/min; 3) 30 eyes (15 dogs) maintained successfully on CsA therapy; 4) 47 eyes (24 dogs) unresponsive to CsA therapy.

STT and clinical signs were evaluated prior to and after 6 to 8 weeks of twice daily tacrolimus administration.

Tacrolimus was substituted for CsA therapy in categories 3 and 4.

The controlled study compared the effect of topical tacrolimus in aqueous suspension to administration of the aqueous carrier alone on tear production in 20 dogs with primary KCS.

Results: In the efficacy study, STT increased by 5 mm/min in 84.7%, 25.0%, 26.7% and 51.1% of eyes in categories 1, 2, 3 and 4 respectively after tacrolimus administration.

Eighty-three percent of eyes with extremely low initial STT ( 2 mm/min), increased 5 mm/min after tacrolimus. In the controlled study, STT increased by 5 mm/min in 7/10 dogs (14/20 eyes) that received tacrolimus and in none of the 10 dogs that received aqueous carrier alone.

Dogs receiving just the aqueous carrier were subsequently treated with tacrolimus, and STT increased 5 mm/min in 9 dogs (18/20 eyes) after administration.

Conclusions: Twice daily administration of 0.02% tacrolimus in aqueous suspension effectively increased tear production in dogs with KCS.

Topical tacrolimus is a promising alternative to topical CsA for treatment of KCS and may be beneficial in patients with less than optimal response to topical CsA.


Source: Berdoulay, Andrew, English, Robert V. & Nadelstein, Brad (2005): Effect of topical 0.02% tacrolimus aqueous suspension on tear production in dogs with keratoconjunctivitis sicca. In: Veterinary Ophthalmology 8 (4), 225-232.




Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Therapy of necrotising fasciitis in a cat
A 10-year-old, domestic shorthair cat was presented for acute lameness of the left forelimb accompanied by severe pain, swelling, skin necrosis, malodorous discharge and pyrexia. Following a presumptive diagnosis of necrotising fasciitis aggressive surgical debridement of the affected soft tissues of the antebrachium and negative pressure wound treatment of the open defect were performed. A fascinating case report about a therapy which is often performed in human medicine but rare in veterinary practice.

  • Carbimazole-associated hypersensitivity vasculitis in a cat with hyperthyroidism
  • SRY-negative 78,XX testicular disorder in a young bitch
  • New surgical technique for feline distal tibial fractures members
  • 5-FU pulse-therapy in canine corneal squamous cell carcinoma members
  • Plasma D-dimer concentration and coagulopathies in horses with colicmembers
  • Third eyelid excision with a CO2 lasermembers
  • Isolation and culture of canine uveal melanocytesmembers
  • Oclacitinib versus prednisolone in dogs with allergic dermatitismembers
  • Three ultrasound guided approaches to the lumbar plexus members
  • Effects of the combination of butorphanol, midazolam and alfaxalone in Beagles members
  • Closed suction drainage in dogs with septic peritonitismembers
  • Equine glaucoma - histopathologic findingsmembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2013 VetContact GmbH
    All rights reserved