Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Privacy Policy  
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
The influence of bimatoprost and unoprostone isopropyl on the intraocular pressure of cats
An interesting and important question: do these eye medications have effects on the paramaters of intraocular pressure (IOP), pupillary diameter (PD), blepharospasm score, conjunctival injection score, and aqueous humor flare score on the eyes of healthy cats?

Either 0.03% bimatoprost solution is applied once daily or 0.15% unoprostone isopropyl solution is applied twice daily topically to the eyes of normal cats.

The aforementioned parameters were evaluated daily in each of 12 cats throughout the entirety of the study.
During an initial 10-day treatment phase a single eye of six of the cats was treated with 0.03% bimatoprost solution while a single eye of the remaining six cats was treated with buffered saline solution (BSS) once daily.

During a second 10-day treatment phase a single eye of six of the cats was treated with 0.15% unoprostone isopropyl solution while a single eye of the remaining six cats was treated with BSS twice daily.
Contralateral eyes of all cats remained untreated at all time points.

Results: Blepharospasm score, conjunctival injection score, and aqueous humor flare score never rose from a value of 0, for any eye of any cat during the study.
The mean ± SD of IOP for eyes treated with 0.03% bimatoprost solution and BSS were 16.55 ± 3.06 mmHg and 18.02 ± 3.52 mmHg, respectively.
The mean ± of PD for eyes treated with 0.03% bimatoprost solution and BSS were 5.7 ± 1.57 mm and 6.39 ± 1.78 mm, respectively.
The mean ± SD of IOP for eyes treated with 0.15% unoprostone isopropyl solution and BSS were 15.7 ± 2.91 mmHg and 17.2 ± 2.9 mmHg, respectively. The mean ± SD of PD for eyes treated with 0.15% unoprostone isopropyl solution and BSS were 5.8 ± 1.43 mm and 6.9 ± 1.37 mm, respectively.

There was no significant difference (P 0.05) in IOP or PD between eyes treated with 0.03% bimatoprost solution vs. eyes treated with BSS.

Similarly, there was no significant difference (P 0.05) in IOP or PD between eyes treated with 0.15% unoprostone isopropyl solution vs. eyes treated with BSS.

Conclusion: Neither once daily topical administration of 0.03% bimatoprost solution nor twice daily topical administration of 0.15% unoprostone isopropyl solution significantly affect the IOP of normal cats.
Both 0.03% bimatoprost solution and 0.15% unoprostone isopropyl solution induced no significant ocular side effects in normal cats when dosed over a 10-day treatment period.


Source: Bartoe, Joshua T., Davidson, Harriet J., Horton, Mary T., Jung, Yoonsung & Brightman, Alan H. (2005): The effects of bimatoprost and unoprostone isopropyl on the intraocular pressure of normal cats. In: Veterinary Ophthalmology 8 (4), 247-252.





Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breedâ€specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breedâ€specific RIs, where appropriate.

  • Metastasis of a well differentiated perianal gland tumor
  • Punica granatum associated with hepatotoxicosis in cattlemembers
  • Toceranib phosphate (Palladia®) in canine gastrointestinal stromal tumorsmembers
  • Radioactive iodine uptake in hyperthyroid cats after rh-TSHmembers
  • Hypoechoic tissue changes in dogs with malignant prostatic lymphomamembers
  • Emphysematous gastritis in dogs and catsmembers
  • Primary pulmonary histiocytic sarcoma in dogsmembers
  • Determining prognosis in canine sepsis members
  • Correlation of plasma and tear glucose, creatinine and urea nitrogen in catsmembers
  • Perineal hernias in dogs - always a bilateral problem?members
  • Pharmacokinetic of gabapentin in catsmembers
  • Follicular development of canine ovaries stimulated by eCG plus hCGmembers


  • [ Home ] [ About ] [ Contact / Request ] [ Privacy Policy ]

    Copyright © 2001-2018 VetContact GmbH
    All rights reserved