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Taurine-reactive cardiomyopathy in related dogs
The role of taurine in the feline heart is well known, as well as the dilated cardiomyopathy as a common and progressive problem in certain large or giant dog breeds. But this extremely interesting recently published case series shows that taurine can be also very important in dogs and that dogs with dilated cardiomyopathy can be successfully treated with taurine.

A reversible taurine-deficient dilated cardiomyopathy occurred in five related golden retrievers.

An apical systolic heart murmur was the most common physical abnormality.

According to fractional shortening and end-systolic diameter on echocardiography, significant improvements (P<0.005) were recorded within 3 to 6 months of starting taurine supplementation.

The dogs regained substantial systolic function, and four were weaned off all cardiac medications except taurine.

This response to therapy was unusual, because canine dilated cardiomyopathy is generally progressive and fatal.



Source: Marie C. Bélanger, Mathieu Ouellet, Guillaume Queney, Maxim Moreau (2005): Taurine-Deficient Dilated Cardiomyopathy in a Family of Golden Retrievers. In: Journal of the American Animal Hospital Association 41:284-291 (2005)



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SMALL ANIMAL PRACTICE

Novel intratumoral therapy in canine transmissible venereal tumour
Canine transmissible venereal tumour (CTVT) is a naturally occurring contagious neoplasm of dogs located mainly on the external genitalia of both sexes. The course of vincristine chemotherapy, the most effective and practical therapy, is affected by the immune status of the host. The aim was to investigate recombinant human interferon alpha‐2a (rhIFNα‐2a) and vincristine for treatment of CTVT.

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