Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
  Interferon  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Intermediate steroid hormone levels in dogs with Alopecia X
Alopecia X remains a skin disease with an unclear pathogenesis. Evaluation of several hormon blood levels have been not very diagnostic in the past. This interesting study compares the interemdiate steroid levels before and during different therapies.

The purpose of the study was to evaluate intermediate adrenal steroid hormones (ISH) in neutered dogs with hair cycle arrest (Alopecia X) during treatment with melatonin, and to see if hair re-growth is associated with sex hormone concentrations within the normal ranges.

Twenty-nine neutered, euthyroid, and normo-cortisolemic dogs were enrolled in the study (23 Pomeranians, three keeshonds, two miniature poodles, and one Siberian husky).

Coat assessment and an ACTH stimulation test were performed pre-treatment and approximately every 4 months for a year post treatment.

Melatonin was administered initially at 3-6 mg, every 12 h. Based on clinical progression, each dog was continued on the current dose of melatonin, given an increased dose of melatonin or changed to mitotane.

Partial to complete hair re-growth occurred in 14/23 Pomeranians, and partial re-growth in 3/3 keeshond and 1/2 poodle dogs. A Siberian husky dog failed to re-grow hair. Fifteen dogs had partial hair re-growth at the first re-evaluation.

Melatonin dosage was increased in eight dogs but only one had improved hair re-growth.

On mitotane treatment, partial to complete hair re-growth was seen in 4/6 dogs and no re-growth in 2/6 dogs.

No significant decrease in sex hormone concentrations were seen during melatonin or mitotane treatment.

Concentrations of ISH in dogs with hair re-growth did not differ significantly from pre-treatment values. At the completion of the study, androstenedione, progesterone and 17-hydroxyprogesterone were still above reference ranges in 21, 64 and 36%, respectively, of dogs with partial to complete hair re-growth.

In conclusion, 62% of dogs had partial to complete hair re-growth. However, not all dogs with hair re-growth had concentrations of ISH within the normal range.


Source: Frank LA, Hnilica KA, Oliver JW. (2004):
Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane. In: Vet Dermatol. 2004 Oct;15(5):278-84.




Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Capsular tension ring use in canine phacoemulsification
Does a capsular tension ring reduce complications in dogs undergoing phacoemulsification and/or intraocular lens Implantation? A very interesting question! The objective of this brandnew study were to evaluate and compare surgical outcome and complications in canine eyes with stable, cataractous lenses undergoing routine phacoemulsification and intraocular lens (IOL) implantation with or without implantation of a capsular tension ring device (CTR).

  • Symmetric Dimethylarginine Serum Concentration and Glomerular Filtration Rate in Cats
  • Intradermal test reactivity and serum allergen-specific IgE measurement for Malassezia pachydermatismembers
  • Treatment of feline corneal sequestrum (FCS) with corneal graftingmembers
  • Effects of Flexion and Extension on the Diameter of the Canine Caudal Cervical Vertebral Canal members
  • Arthroscopic Treatment of Young Large Breed Dogs With Medial Compartment Disease of the Elbowmembers
  • Topical 1% 5-fluorouracil in a young dog with corneal squamous cell carcinomamembers
  • Perioperative Antimicrobials During Tibial Plateau Leveling Osteotomymembers
  • Serum and urine Blastomyces antigen as markers of clinical remissionmembers
  • Association between vitreous degeneration and cataract in dogsmembers
  • Capsular tension ring use in dogs with phacoemulsification and IOL implantationmembers
  • Minocycline in meticillin-resistant Staphylococcus pseudintermedius infectionsmembers
  • Ultrasound biomicroscopy of the normal canine haired skinmembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2013 VetContact GmbH
    All rights reserved