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Adult-Onset Cerebellar Cortical Abiotrophy and Retinal Degeneration in a cat
Ataxia and visual deficits are common reasons to present a cat at the veterinarian. There are many differentials to consider. But this is a very unusual one: an adult-onset cerebellar cortical abiotrophy and retinal degeneration. The diagnosis was made post mortem!

A 4-year-old, neutered male domestic shorthair cat presented for evaluation of ataxia and visual deficits.

Neurological examination revealed severe cerebellar ataxia with symmetrical hypermetria and spasticity, a coarse whole-body tremor, positional vertical nystagmus, and frequent loss of balance.

A menace response was absent bilaterally, and the pupils were widely dilated in room light.

A funduscopic examination revealed markedly attenuated to absent retinal vessels and pronounced tapetal hyperreflectivity, findings consistent with end-stage retinal degeneration.

Blood work evaluation included retroviral testing, a complete blood count, serum biochemistry analysis, taurine levels, and toxoplasma immunoglobulin G and immunoglobulin M titers. All were within reference ranges.

The patient was euthanized, and a necropsy was performed.

Microscopically, lesions of the nervous system were confined to the cerebellum and were consistent with cerebellar cortical abiotrophy. Selective photoreceptor degeneration was seen on histopathological examination of the retina with a reduction in the number of rods and cones.

The combination of clinical findings and histopathological lesions seen here has not been previously reported in the cat.


Source: Georgina Barone, Polly Foureman, Alexander deLahunta (2002): Adult-Onset Cerebellar Cortical Abiotrophy and Retinal Degeneration in a Domestic Shorthair Cat. In: Journal of the American Animal Hospital Association 38:51-54 (2002)



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SMALL ANIMAL PRACTICE

The expression of Vitamin D receptors in dogs
There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and in dogs. Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Little is known about which non-skeletal tissues express the VDR or how inflammation influences its expression in the dog.
The objectives of this recently online published study were to define which non-skeletal canine tissues express the VDR and to investigate expression in inflamed small intestine.

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