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Prevalence of house dust mite-antigen in houses with and without dogs
A very interesting study with surprising results! House dust mite allergens, which are described as the most common allergens in dogs and men with atopy, are found in living rooms in high concentrations - not surprising. But their concentration is significantly higher in the households without dogs - really surprising. Is flea prevention the explanation for this?

Dermatophagoides farinae is a frequent allergen in canine atopic dermatitis despite its reported scarcity in the UK, and the aim of this study was to determine whether dogs were uniquely exposed to this species.

Der f 1 and Der p 1 in dust collected from living room carpets, bedroom carpets and dog beds of 13 houses with no dogs, 13 with healthy dogs, and 16 with Dermatophagoides-sensitized atopic dogs were quantified by ELISA.

Der p 1 levels (Āµg g1 house dust) were significantly higher than Der f 1 in living rooms (Der p 1 median = 1.9, 95% CI = 2.056.32, n = 42; Der f 1 median = 0.07, 95% CI = 0.010.06, n = 42), bedrooms (Der p 1 median = 4.35, SD = 5.52; Der f 1 median = 0.01, 95% CI = 0.0010.1, n = 42) and dog beds (Der p 1 median = 1.04, 95% CI = 1.48.1, n = 29; Der f 1 median = 0.008, 95% CI = 0.010.04, n = 29) (P < 0.0001).

Living rooms in houses without dogs had significantly greater Der p 1 levels (median = 7.0, 95% CI = 3.5315.8, n = 13) than houses with healthy (median = 1.19, 95% CI = 0.443.49, n = 13) or atopic dogs (median = 0.78, 95% CI = 0.632.42, n = 16) (P = 0.0004).

Environmental flea control in living rooms and washing dog beds was associated with significantly reduced Der p 1 levels.

This confirms that D. pteronyssinus is common but D. farinae is rare in the sampling area.

Apparent sensitization to D. farinae is probably due to cross-reaction.
A combination of environmental measures could reduce allergen exposure.


Source: RAFFAN, ELEANOR, LAWRENCE, HELEN, HENDERSON, THOMAS, NELSON, SARAH, ISHERWOOD, DIANA, McARDLE, CLAIRE & NUTTALL, TIM (2005): Prevalence of the group 1 Dermatophagoides allergens Der p 1 and Der f 1 in homes with no dogs, healthy dogs and Dermatophagoides-sensitized atopic dogs in Liverpool. In: Veterinary Dermatology 16 (4), 253-260.





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SMALL ANIMAL PRACTICE

Aldosterone-Āproducing adrenocortical carcinoma with myxoid differentiation in a Persian cat
A 10ā€yearā€old male neutered Persian cat was presented with an abdominal mass and history of weakness. Blood smear examination found marked elliptocytosis, and serum biochemical analysis revealed hypokalemia, hypochloremia, increased creatine kinase activity, and a high aldosterone concentration. Cytologic examination of the mass revealed neoplastic endocrine cells with moderate criteria of malignancy, favoring adrenocortical neoplasia. A very interesting case report!

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