Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Privacy Policy  
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Equine /     
 
Pharmacokinetics of acyclovir in adult healthy horses
Acyclovir is an antiviral drug which is commonly used in human medicine, especially in treating herpes labialis infections. Sometimes it is also used in horses but less is known about its pharmakokinetics. An interesting study - who knew that the substance does not reach therapeutical levels after oral adminisration?

Acyclovir was administered IV (10 mg/kg in 1 L isotonic crystalloid solution over 60 minutes) and orally (20 mg/kg) to healthy adult horses.

Plasma samples were obtained and acyclovir concentrations were determined by high-pressure liquid chromatography.

Peak concentration (mean±SD) for IV acyclovir was 13.74±5.88 g/mL at the completion of the 1-hour infusion.

The half-life of the distribution phase () was 0.16 hours while the half-life of the elimination phase () was 9.6 hours.
The steady-state volume of distribution was 3.93±1.21 L/kg.

We were unable to measure pharmacokinetics after PO acyclovir as plasma concentrations were below the lower limits of detection in all 6 horses.

Conclusions: IV administration of acyclovir to healthy adult horses achieves concentrations within the sensitivity range described for equine herpes virus-type 1.

The oral bioavailability of acyclovir in horses is low and additional studies are required.



Source: Wilkins, Pamela A., Papich, Mark & Sweeney, Raymond W. (2005): Pharmacokinetics of acyclovir in adult horses. In: Journal of Veterinary Emergency and Critical Care 15 (3), 174-178.





Tell a friend   |   Print version   |   Send this article

EQUINE

Presumed Neuroglycopenia following Severe Hypoglycemia in Horsesmembers
Neuroglycopenia refers to a shortage of glucose in the brain resulting in neuronal dysfunction and death if left untreated. Presumed neuroglycopenia has not been described in horses. Thus, the objective of this retrospective study was to report neurological signs in horses with presumed neuroglycopenia as the result of severe hypoglycemia.

  • E321G MYH1 mutation and nonexertional rhabdomyolysis in Quarter Horsesmembers
  • Novel therapeutic approach for mares with suspected uterine tubal blockagemembers
  • Unusual cause of unilateral facial swelling in a coltmembers
  • Novel topical therapy of equine sarcoidsmembers
  • Conventional radiography versus CT to diagnose osteomyelitis in foalsmembers
  • Novel surgical treatment of recurrent laryngeal neuropathy in horses members
  • Standing repair of a fracture of the third metatarsal bone of a Hunt Thoroughbred mare members
  • Unusual cause of bilateral blindness in a young Quarter Horsemembers
  • Advanced imaging of an incomplete fracture of Os metacarpale III in a young Warmbloodmembers
  • Equine external beam radiation therapymembers
  • Insulin dysregulation in horses with SIRSmembers
  • The farrier role in supporting horse owners to prevent laminitismembers


  • [ Home ] [ About ] [ Contact / Request ] [ Privacy Policy ]

    Copyright © 2001-2018 VetContact GmbH
    All rights reserved