Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Privacy Policy  
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Equine /     
 
Pharmacokinetics of acyclovir in adult healthy horses
Acyclovir is an antiviral drug which is commonly used in human medicine, especially in treating herpes labialis infections. Sometimes it is also used in horses but less is known about its pharmakokinetics. An interesting study - who knew that the substance does not reach therapeutical levels after oral adminisration?

Acyclovir was administered IV (10 mg/kg in 1 L isotonic crystalloid solution over 60 minutes) and orally (20 mg/kg) to healthy adult horses.

Plasma samples were obtained and acyclovir concentrations were determined by high-pressure liquid chromatography.

Peak concentration (mean±SD) for IV acyclovir was 13.74±5.88 g/mL at the completion of the 1-hour infusion.

The half-life of the distribution phase () was 0.16 hours while the half-life of the elimination phase () was 9.6 hours.
The steady-state volume of distribution was 3.93±1.21 L/kg.

We were unable to measure pharmacokinetics after PO acyclovir as plasma concentrations were below the lower limits of detection in all 6 horses.

Conclusions: IV administration of acyclovir to healthy adult horses achieves concentrations within the sensitivity range described for equine herpes virus-type 1.

The oral bioavailability of acyclovir in horses is low and additional studies are required.



Source: Wilkins, Pamela A., Papich, Mark & Sweeney, Raymond W. (2005): Pharmacokinetics of acyclovir in adult horses. In: Journal of Veterinary Emergency and Critical Care 15 (3), 174-178.





Tell a friend   |   Print version   |   Send this article

EQUINE

The farrier role in supporting horse owners to prevent laminitismembers
Emerging research highlights how, due to demographic changes in horse owner populations in Western societies, complex owner–horse relationships are leading to inappropriate horse care, including overnutrition, which in turn can lead to laminitis. Farriers, due to their regular visits, may be in a position to support owners in dealing with this problem. This study explored whether UK farriers have a role in working with horse owners to support horse welfare and prevent laminitis.

  • CT description of equine oromaxillary sinus and oronasal fistulaemembers
  • Insulin and the structural integrity of equine digital lamellaemembers
  • Exercise-induced pulmonary haemorrhage in Thoroughbred racehorsesmembers
  • Specific bioactive collagen peptides (PETAGILE®) in horses with osteoarthritismembers
  • Epidural anaesthesia in horses with perineal and tail melanomasmembers
  • Unexpected cause of haematuria in an Egyptian Arabian stallionmembers
  • First description of hypersplenism in an old miniature ponymembers
  • Endocrinopathies associated with severe hypertriglyceridaemia in horses and poniesmembers
  • Clinical effect of corticosteroids in horses with asthmamembers
  • Severe complications of cheek tooth extraction in a ponymembers
  • Septic keratitis - associated bacteria and antibiotic susceptibilitymembers
  • Traumatic coccygeal luxation and distal amputation of the tail of a horsemembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved