Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Privacy Policy  
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Equine /     
 
Pharmacokinetics of acyclovir in adult healthy horses
Acyclovir is an antiviral drug which is commonly used in human medicine, especially in treating herpes labialis infections. Sometimes it is also used in horses but less is known about its pharmakokinetics. An interesting study - who knew that the substance does not reach therapeutical levels after oral adminisration?

Acyclovir was administered IV (10 mg/kg in 1 L isotonic crystalloid solution over 60 minutes) and orally (20 mg/kg) to healthy adult horses.

Plasma samples were obtained and acyclovir concentrations were determined by high-pressure liquid chromatography.

Peak concentration (mean±SD) for IV acyclovir was 13.74±5.88 g/mL at the completion of the 1-hour infusion.

The half-life of the distribution phase () was 0.16 hours while the half-life of the elimination phase () was 9.6 hours.
The steady-state volume of distribution was 3.93±1.21 L/kg.

We were unable to measure pharmacokinetics after PO acyclovir as plasma concentrations were below the lower limits of detection in all 6 horses.

Conclusions: IV administration of acyclovir to healthy adult horses achieves concentrations within the sensitivity range described for equine herpes virus-type 1.

The oral bioavailability of acyclovir in horses is low and additional studies are required.



Source: Wilkins, Pamela A., Papich, Mark & Sweeney, Raymond W. (2005): Pharmacokinetics of acyclovir in adult horses. In: Journal of Veterinary Emergency and Critical Care 15 (3), 174-178.





Tell a friend   |   Print version   |   Send this article

EQUINE

Limbal squamous cell carcinoma in a Rocky Mountain Horse and geneticsmembers
One privately owned Rocky Mountain Horse and 84 Rocky Mountain Horses screened for allelic frequency were enrolled in this study. The objective: To document a case of limbal squamous cell carcinoma (SCC) in a Rocky Mountain Horse stallion determined to be homozygous for the genetic risk factor (DDB2 c.1013C>T) strongly associated with the disease in Haflinger and Belgian horses, and to determine the frequency of this allele in a larger population of Rocky Mountain Horses.

  • Subconjunctival bupivacaine, lidocaine, and mepivacaine and the corneal sensitivity in horsesmembers
  • Clodronate in horses with lamenessmembers
  • Valacyclovir in horses with equine multinodular pulmonary fibrosismembers
  • Radiculopathy associated with forelimb lameness in horsesmembers
  • Biological variations of routine blood parameters in horsesmembers
  • Prognosis for horses with deep digital flexor tendon injury after penetrating woundmembers
  • Possible maternal effect for the pace trait of horsesmembers
  • Flecainide on induced atrial fibrillation in horsesmembers
  • Sonographic technique to identify manica flexoria tears in horsesmembers
  • Novel prototype dynamic laryngoplasty system on arytenoid abductionmembers
  • Lipid peroxidation biomarkers in equine neuroaxonal dystrophymembers
  • Eosinophils of the horse: an updatemembers


  • [ Home ] [ About ] [ Contact / Request ] [ Privacy Policy ]

    Copyright © 2001-2018 VetContact GmbH
    All rights reserved