|Six dogs were diagnosed with pemphigus foliaceus based on suggestive clinical signs and histopathology.
These patients were treated either with immunosuppressive doses of oral glucocorticoids or with a combination of oral glucocorticoids and azathioprine.
After clinical signs underwent complete remission, which occurred 1.5-5 months after immunosuppression was initiated, the drugs were tapered progressively and eventually withdrawn.
The total duration of immunosuppressive therapy varied between 3 and 22 months.
Skin lesions of pemphigus foliaceus did not recur for 1.5-6 years after treatment was stopped.
These observations suggest that, in some dogs with pemphigus foliaceus, immunosuppression can lead to long-term remission of skin lesions, and that discontinuation of treatment is not necessarily followed by a recurrence of clinical signs.
Source: Olivry T, Bergvall KE, Atlee BA. (2004): Prolonged remission after immunosuppressive therapy in six dogs with pemphigus foliaceus. In: Vet Dermatol. 2004 Aug;15(4):245-52.
Tell a friend
Send this article