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Prolonged remission time after pemphigus foliaceus therapy in dogs
Pemphigus foliaceus is one of the most common autoimmune diseases in dogs. Limited information is available on the long-term outcome of treatment of this disease. If life-long immunosuppressive therapy always mandatory? Interesting answers come from this study. It reports that a prolonged remission can occur after discontinuation of immunosuppressive regimens in some animals with this disease.

Six dogs were diagnosed with pemphigus foliaceus based on suggestive clinical signs and histopathology.

These patients were treated either with immunosuppressive doses of oral glucocorticoids or with a combination of oral glucocorticoids and azathioprine.

After clinical signs underwent complete remission, which occurred 1.5-5 months after immunosuppression was initiated, the drugs were tapered progressively and eventually withdrawn.

The total duration of immunosuppressive therapy varied between 3 and 22 months.

Skin lesions of pemphigus foliaceus did not recur for 1.5-6 years after treatment was stopped.

These observations suggest that, in some dogs with pemphigus foliaceus, immunosuppression can lead to long-term remission of skin lesions, and that discontinuation of treatment is not necessarily followed by a recurrence of clinical signs.



Source: Olivry T, Bergvall KE, Atlee BA. (2004): Prolonged remission after immunosuppressive therapy in six dogs with pemphigus foliaceus. In: Vet Dermatol. 2004 Aug;15(4):245-52.



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