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Funisitis associated with leptospiral infection in a horse
Funisitis, inflammation of the umbilical cord, is well recognized in human placentas and not very common in horses. And Leptospira infections in horses are well-known to be involved in chronic eye infections. A very informative case report of a funisitis associated with leptospiral infection in the placenta of a Thoroughbred foal born prematurely.

The umbilical cord had diffuse superficial yellow discoloration along its entire length.

Microscopic evaluation showed an exudate of neutrophils admixed with fibrin on the surface. Warthin–Starry staining showed spirochetes in the Wharton`s jelly of the umbilical cord.

A locally extensive, severe placentitis not involving the star and allantoic cystic hyperplasia were the other lesions observed in the allantochorion.

Leptospira funisitis is similar to the funisitis of congenital syphilis in humans, although there are some major microscopic differences.

In Leptospira funisitis, lesions were limited to the cord surface, whereas in lesions in human umbilical cords with Treponema pallidum infection, the changes are observed mostly around the vessels and in the Wharton`s jelly.


Source: M. Sebastian, R. Giles, J. Roberts, K. Poonacha, L. Harrison, J. Donahue and K. Benirschke (2005): Funisitis Associated with Leptospiral Abortion in an Equine Placenta. In: Vet Pathol 42:659-662 (2005)



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EQUINE

Valacyclovir in horses with equine multinodular pulmonary fibrosismembers
Equine herpesvirus‐5 is commonly isolated from the lungs of horses with EMPF, suggesting an etiological link. Valacyclovir is used empirically to treat EMPF; however, no data is available concerning its impact on EHV‐5 viral kinetics. The objectives of this study were to determine the effect of oral administration of valacyclovir on EHV‐5 viral load measured by qPCR in blood, nasal secretions (NS) and BALF in horses with EMPF on six horses diagnosed with EMPF.

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