This type of pseudothrombocytopenia is not a pathological process by itself, but it can be clinically significant if diagnostics and medical treatments are initiated based on the reported thrombocytopenia.
Platelet clumping occurs with EDTA-dependent PTCP, resulting in inaccurate hematology analyzer platelet concentrations.
A nontraumatic venipuncture may be sufficient to obtain an accurate platelet count.
However, rare cases in the dog may require blood drawn into a different anticoagulant, such as sodium citrate, to help discriminate a true thrombocytopenia from PTCP.
Source: Tamara B. Wills, K. Jane Wardrop (2008):Pseudothrombocytopenia Secondary to the Effects of EDTA in a Dog. In: Journal of the American Animal Hospital Association 44:95-97 (2008)
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