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Post operative infection and perioperative antimicrobial drugs use in surgical colic patients
Infections are common complications in post operative colic patients. It is the impression of some surgeons that pyrexia in the early post operative period is a sign of infection and appropriate timing of perioperative antimicrobials will decrease the incidence of post operative infection. In this study on more than 100 horses, the association between 1) post operative pyrexia and development of infection and 2) perioperative antimicrobial drug use and infection rate in post operative colic patients was investigated.


Medical records of patients undergoing surgical treatment for colic were reviewed.

Horses recovering from surgery and surviving >48 h were included.

Data relating to case details, duration of surgery, post operative infection, peri- and post operative antimicrobial administration, presence, intensity and duration of pyrexia, were recorded.

Data were analysed using standard statistical methods for simple comparisons between groups and by logistic regression for more complex comparisons.

Results: One-hundred-and-thirteen horses were included in the final analyses, 48 (43%) of which were diagnosed with a post operative infection.

Duration of surgery and anaesthesia were associated with post operative infection.

Eighty-five percent of horses (n = 96) exhibited pyrexia (rectal temperature >38.3°C) post operatively.

Peak temperature >39.2°C, time post surgery to peak temperature >48 h and duration of pyrexia >48 h were significantly associated with infection.

In a combined model, time to first pyrexic >48 h post surgery, peak temperature and time to peak >48 h were equally weighted and the model`s positive predictive value for post operative infection was 72%.

Timing and dose rate of preoperative antimicrobials were not associated with infection but duration of post operative antimicrobial drug use was.

Conclusion and clinical relevance: Slight to mild pyrexia (38–39.4°C) in the early post operative period is not necessarily associated with impending bacterial infection in colic patients and the use of antimicrobials in these patients may be costly and unnecessary.


Source: FREEMAN, K. D., SOUTHWOOD, L. L., LANE, J., LINDBORG, S. and ACETO, H. W. (2012), Post operative infection, pyrexia and perioperative antimicrobial drug use in surgical colic patients. Equine Veterinary Journal, 44: 476–481. doi: 10.1111/j.2042-3306.2011.00515.x





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EQUINE

Theiler´s disease in a Trakehner caused by contaminated tetanus vaccinemembers
An 11â€yearâ€old Trakehner gelding was presented for evaluation of lethargy, decreased appetite, mild icterus, and elevated hepatic enzyme activities. Physical examination, serum chemistry results, and liver biopsy histopathologic findings were supportive of Theiler`s disease. Polymerase chain reaction (PCR) testing results of serum and liver tissue were positive for nonprimate (equine) hepacivirus (NPHV) and a novel equine parvovirusâ€hepatitis virus (EqPVâ€H). A serious and finally fatal problem, caused by contaminated vaccine.

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