Hepatoblastoma was diagnosed in 3 Thoroughbreds at the University of Kentucky Livestock Disease Diagnostic Center (LDDC) since 1997.
Case #1 involved a fetus with a well-demarcated, multilobulated, solitary mass that extended from the left liver lobe.
Case #2 was observed in a neonate with a primary hepatic mass and multiple metastases in the skin, brain, meninges, and stylohyoid bone.
Case #3 was a solitary hepatic mass incidentally discovered in a neonate at necropsy.
Microscopically, the masses were similarly composed of sheets and cords of fetal and embryonal epithelial cells that frequently formed sinusoid-like structures.
Intermixed with the neoplastic epithelial cells were variable amounts of hemorrhage, necrosis, osteoid, and bone.
Immunohistochemically, the epithelial cells stained variably positive for alpha- fetoprotein, frequently positive for vimentin, and occasionally positive for cytokeratin.
All 3 cases were diagnosed as mixed hepatoblastoma with teratoid features.
Source: A. T. Loynachan, D. C. Bolin, C. B. Hong and K. B. Poonacha (2007): Three Equine Cases of Mixed Hepatoblastoma with Teratoid Features. In: Vet Pathol 44:211-214 (2007)
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