Fifty-four dogs with CKD and 22 healthy dogs were included in this study.
Blood and urine samples were obtained for a CBC, biochemistry, determination of parathyroid hormone (PTH), calcitriol, and ionized calcium concentrations and urinalysis. Based on urine protein/creatinine ratio and serum creatinine concentration, dogs were grouped according to the IRIS classification for CKD.
Results: Hyperparathyroidism (HPTH) (PTH ¡Ý 48 pg/mL) was diagnosed in 41 (75.9%) dogs with CKD. Its prevalence increased from 36.4% (stage 1) to 100% (stage 4).
Hyperphosphatemia (P > 5.5 mg/dL) was present in 37 (68.5%) dogs; increasing in prevalence from 18% (stage 1) to 100% (stage 4).
Receiver-operating characteristic curve analysis showed that serum phosphorus concentration in the 4.5¨C5.5 mg/dL range correctly identified the presence of HPTH in most dogs.
Calcitriol concentration progressively decreased in dogs with CKD and differences became statistically significant by stage 3.
Conclusion and Clinical Relevance: HPTH and hyperphosphatemia occur frequently in dogs with naturally occurring CKD, even at early stages of CKD in some dogs. These findings highlight the importance of monitoring these parameters early in the course of CKD.
Source: O. Cortadellas, M.J. Fern¨¢ndez del Palacio, J. Talavera, A. Bay¨®n (2010): Calcium and Phosphorus Homeostasis in Dogs with Spontaneous Chronic Kidney Disease at Different Stages of Severity. In: Journal of Veterinary Internal Medicine
Volume 24 Issue 1, Pages 73 - 79
Published Online: 17 Nov 2009
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