Thus, further discovery is necessary but such efforts have been thwarted by genetic heterogeneity.
Reducing heterogeneity is key, and studying isolated human populations have helped in the endeavour.
An alternative is to study dog pedigrees, since artificial selection has resulted in extreme homogeneity.
Identifying the genetic predisposition to canine mammary tumours can translate to human discoveries – a strategy currently underutilized.
To explore this potential, we reviewed published canine mammary tumour genetic studies and proposed benefits of next generation sequencing canine cohorts to facilitate moving beyond incremental advances.
The complete Review article can be seen for free here:
Source: Goebel, K. and Merner, N. D. (2017), A monograph proposing the use of canine mammary tumours as a model for the study of hereditary breast cancer susceptibility genes in humans. Veterinary Medicine and Scienc. doi: 10.1002/vms3.61
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