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Oncology Home ONCOLOGY
HYPOECHOIC TISSUE CHANGES IN DOGS WITH MALIGNANT PROSTATIC LYMPHOMA
Neoplasia of the prostate is relatively uncommon in dogs with adenocarcinoma being the most common type. Nonâ€epithelial tumors are rare and only individual cases of malignant lymphoma affecting the prostate have been reported. The purpose of this multiâ€institutional, retrospective, descriptive study was to characterize the ultrasonographic features of canine prostatic lymphoma. Inclusion criteria were an abdominal ultrasound and cytological/histological diagnosis of malignant prostatic lymphoma.

Ultrasonographic features were recorded based on the original ultrasonographic reports and consensus opinion of two readers on the available image sets retrospectively.

Nine dogs met the inclusion criteria with a mean age of 6.5 years.

Seven dogs were intact and two neutered.

Subjective prostatomegaly was noted in all patients however not reproducible by objective measurements.

Altered shape with rounded/irregular margins was detected in 78% of the cases.

All prostates presented either diffuse (three dogs) or focal/periurethral (four dogs) and/or multifocal areas of hypoechogenicity (three dogs).

In one dog, focal and multifocal hypoechoic changes coâ€occurred.

Prostatic mineralization was not present in any of the cases.

Ultrasonographic features of infiltrative disease of multiple organs and/or lymphadenopathy was found in all cases.

Even though malignant lymphoma is rare in the prostate, it should be included in the list of differentials in patients with hypoechoic lesions/areas, altered shape, lack of mineralization of the prostatic parenchyma and evidence of multiorgan involvement.


Source: Pamela Di Donato Raffaela Zweifel Kernt Koehler Lorenzo Golini Lorenzo Ressel Martin Kramer Ingmar Kiefer Chee Kin Lim Nele Ondreka, Predominance of hypoechoic tissue changes in nine dogs with malignant prostatic lymphoma. VRU, Early View. First published: 21 September 2018 https://doi.org/10.1111/vru.12686

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Toceranib phosphate (Palladia®) in canine gastrointestinal stromal tumors Gastrointestinal stromal tumors (GISTs) are uncommon intestinal neoplasms in the dog. Literature regarding adjunctive therapy for GISTs in dogs is sparse. Highâ€risk GISTs in humans respond to tyrosine kinase inhibition in the adjuvant setting. This recently online published study reviews cases of toceranib phosphate use in dogs with GISTs and provides initial assessment of possible biological activity. A secondary aim was to evaluate patient and tumor characteristics for possible prognostic value.

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