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Cyproheptadine in cats
Cyproheptadine is sometmes used in cats to stimulate their appetite. What about the distribution in the body after oral or intravenous application? The results of this study give interesting informations...

The objective of this study including 6 healthy cats was to determine disposition of cyproheptadine hydrochloride in cats after intravenous or oral administration of a single dose. A randomized crossover design was used, and each cat was studied after intravenous (2 mg) and oral (8 mg) administration of cyproheptadine.

Blood samples were collected at fixed time intervals after drug administration, and serum cyproheptadine concentration was determined by means of polarized immunofluorescence.

RESULTS: Mean (+/- SD) residence time was significantly longer after oral (823 +/- 191 minutes) than after intravenous (339 +/- 217 minutes) administration, but no significant differences were detected between other pharmacokinetic parameters after oral and intravenous administration.

Mean +/- SD oral bioavailability was 1.01 +/- 0.36.

Mean elimination half-life after oral administration was 12.8 +/- 9.9 hours. Peak extrapolated cyproheptadine concentration was 669 +/- 206 ng/ml. Only 1 cat developed adverse effects (transient vocalization).

CONCLUSIONS: Cyproheptadine appeared to be well tolerated in cats and had high bioavailability after oral administration. The mean elimination half-life of 12 hours indicated that approximately 2.5 days must elapse to achieve steady-state concentrations of cyproheptadine after oral administration of multiple doses. A 12-hour dosing interval is acceptable, but an 8-hour interval may be indicated for some cats.

On the basis of pharmacokinetic parameters determined in this study, the oral form of cyproheptadine appears to be suitable for use in clinical trials to treat anorexia in cats. Its half-life is compatible with once or twice daily dosing.


Source: Norris CR, Boothe DM, Esparza T, Gray C, Ragsdale M. (1998): Disposition of cyproheptadine in cats after intravenous or oral administration of a single dose. In: Am J Vet Res. 1998 Jan;59(1):79-81.



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SMALL ANIMAL PRACTICE

Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a Rat terrier
A female neutered Rat Terrier was presented for an acute onset of seizure‐like episodes, weakness, and vomiting approximately 14 hours after ingestion of 198 mg/kg of metformin. The dog was found to be laterally recumbent, paddling, and unresponsive shortly before presentation. On physical exam, the dog was in hypovolemic shock and hypothermic. It was finally diagnosed as severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. This case report describes diagnosis and therapy.

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