Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
New chemotherapy protocol for canine lymphoma
Different protocols exist to treat lymphomas in dogs, almost all of them base on a remission protocol followed by a maintenance protocol. This study compares a maintenance-free chemotherapy protocol based on CHOP (H from hydroxydaunorubicin = doxorubicin, O from Oncovin = vincristine) to a similar protocol with a maintenance phase for the treatment of canine lymphoma.

Fifty-three dogs with multicentric lymphoma were treated with a 6-month modified version of the University of Wisconsin (UW)-Madison chemotherapy protocol (UW-25). Disease-free interval (DFI) and survival were compared to a historical control group of 55 dogs treated with a similar protocol with a prolonged maintenance phase. Remission rate for the study dogs was 94.2% (complete remission = 92.3%, partial remission = 1.9%). DFI and survival between the 2 groups did not differ significantly, with median DFI and survival of the study dogs equal to 282 and 397 days compared to 220 and 303 days for the control dogs (P = .2835 and .3365, respectively). Univariate analysis identified substage b (P = .0087), German Shepherd breed (P = .0199), and body weight > 18 kg (P = .0016) as significant for worse survival. Longer survival was associated with thrombocytopenia (P = .0436). Multivariate analysis revealed that substage (P = .0388) and weight (P = .0125) retained significance for DFI, whereas substage (P = .0093), thrombocytopenia (P = .0150), and weight (P = 0 .0050) retained significance for survival. Overall, the protocol was well tolerated by the dogs, with 41.5% (22/53) requiring a treatment delay or dose modification, but only 9.4% (5/53) needing hospitalization. The 6-month chemotherapy protocol based on CHOP with no maintenance phase provides similar DFI and survival times when compared to a similar protocol with a prolonged maintenance phase.


Source: Garrett LD, Thamm DH, Chun R, Dudley R, Vail DM (2002): Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma. In: J Vet Intern Med 2002 Nov-Dec;16(6):704-9






Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

ROTEM reference values in healthy catsmembers
Rotational thromboelastometry (ROTEM) is a precise diagnostic option, but unfortunately the reference values using feline blood are not well defined. Twenty-three clinically healthy cats between 1 and 15 years were enrolled in this prospective study to define reference values.

  • Malignant anal sac melanoma in dogs
  • Topical hyaluronic acid on corneal wound healing in dogsmembers
  • Lomustine (Cecenu) in cats with intermediate to large cell gastrointestinal lymphoma members
  • Bartonella henselae in canine cavitary effusions - an underdiagnosed problem?members
  • Vomitus in dogs with pericardial effusionmembers
  • Hemostatic Findings in Ascitic Fluid of Dogsmembers
  • Balloon Valvuloplasty of Tricuspid Stenosis in Labrador Retrieversmembers
  • Occult gastrointestinal bleeding in dogs with chronic kidney diseasemembers
  • Modified tibial compression test for the detection of meniscal injurymembers
  • Prophylactic topical hypotensive medications to reduce ocular hypertension after phacoemulsificationmembers
  • Review to avian paramyxovirusmembers
  • Multiple myeloma and mast cell neoplasia in an old catmembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved