Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
  Interferon  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
New chemotherapy protocol for canine lymphoma
Different protocols exist to treat lymphomas in dogs, almost all of them base on a remission protocol followed by a maintenance protocol. This study compares a maintenance-free chemotherapy protocol based on CHOP (H from hydroxydaunorubicin = doxorubicin, O from Oncovin = vincristine) to a similar protocol with a maintenance phase for the treatment of canine lymphoma.

Fifty-three dogs with multicentric lymphoma were treated with a 6-month modified version of the University of Wisconsin (UW)-Madison chemotherapy protocol (UW-25). Disease-free interval (DFI) and survival were compared to a historical control group of 55 dogs treated with a similar protocol with a prolonged maintenance phase. Remission rate for the study dogs was 94.2% (complete remission = 92.3%, partial remission = 1.9%). DFI and survival between the 2 groups did not differ significantly, with median DFI and survival of the study dogs equal to 282 and 397 days compared to 220 and 303 days for the control dogs (P = .2835 and .3365, respectively). Univariate analysis identified substage b (P = .0087), German Shepherd breed (P = .0199), and body weight > 18 kg (P = .0016) as significant for worse survival. Longer survival was associated with thrombocytopenia (P = .0436). Multivariate analysis revealed that substage (P = .0388) and weight (P = .0125) retained significance for DFI, whereas substage (P = .0093), thrombocytopenia (P = .0150), and weight (P = 0 .0050) retained significance for survival. Overall, the protocol was well tolerated by the dogs, with 41.5% (22/53) requiring a treatment delay or dose modification, but only 9.4% (5/53) needing hospitalization. The 6-month chemotherapy protocol based on CHOP with no maintenance phase provides similar DFI and survival times when compared to a similar protocol with a prolonged maintenance phase.


Source: Garrett LD, Thamm DH, Chun R, Dudley R, Vail DM (2002): Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma. In: J Vet Intern Med 2002 Nov-Dec;16(6):704-9






Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Symmetric Dimethylarginine Serum Concentration and Glomerular Filtration Rate in Cats
Direct measurement of glomerular filtration rate (GFR) is the preferred method to assess renal function in cats, but it is not widely used in the diagnosis of chronic kidney disease (CKD). In cats with CKD, symmetric dimethylarginine (SDMA) has been shown to increase and to correlate with plasma creatinine concentrations. Does a reduced GFR correspond with increased serum SDMA concentration?

  • Intradermal test reactivity and serum allergen-specific IgE measurement for Malassezia pachydermatismembers
  • Treatment of feline corneal sequestrum (FCS) with corneal graftingmembers
  • Effects of Flexion and Extension on the Diameter of the Canine Caudal Cervical Vertebral Canal members
  • Arthroscopic Treatment of Young Large Breed Dogs With Medial Compartment Disease of the Elbowmembers
  • Topical 1% 5-fluorouracil in a young dog with corneal squamous cell carcinomamembers
  • Perioperative Antimicrobials During Tibial Plateau Leveling Osteotomymembers
  • Serum and urine Blastomyces antigen as markers of clinical remissionmembers
  • Association between vitreous degeneration and cataract in dogsmembers
  • Capsular tension ring use in dogs with phacoemulsification and IOL implantationmembers
  • Minocycline in meticillin-resistant Staphylococcus pseudintermedius infectionsmembers
  • Ultrasound biomicroscopy of the normal canine haired skinmembers
  • Effects of aloe vera on corneal wound closure and collagenase activitymembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2013 VetContact GmbH
    All rights reserved