8 adult horses were included in this randomized, cross-over experimental designed study.
Synovial fluid was aseptically collected from the DFTS and either 1 mL amikacin sulfate (250 mg/mL) or lactated Ringer`s solution (LRS) was injected into the DFTS. Serial synovial fluid samples were obtained at 0, 12, 24, 48, and 72 hours. The opposite treatment was administered to the contralateral DFTS after a washout period of 2 weeks.
Treatment increased TP concentration, TNCC, percentage of neutrophils, and neutrophil counts from baseline levels. There was no difference between treatment of the DFTS with amikacin or LRS. Values peaked at 12–24 hours after the initial centesis and then declined toward baseline levels.
Injection and repeat centesis of the normal DFTS with 250 mg amikacin or an equivalent volume of LRS resulted in mild increases in synovial fluid analytes from baseline. Synovial inflammation in this study was not accompanied by lameness at the walk and measured analytes returned toward baseline levels within 12–24 hours of first injection.
The effect of tenovaginocentesis and intrathecal administration of amikacin or LRS on DFTS synovial fluid values are modest in most horses; however, some horses can develop marked increases in synovial fluid values that may be interpreted as sepsis.
Source: SUSANNE DYKGRAAF, JULIE E. DECHANT, JENNIFER L. JOHNS, MARY M. CHRISTOPHER, DAVID M. BOLT, JACK R. SNYDER (2007):Effect of Intrathecal Amikacin Administration and Repeated Centesis on Digital Flexor Tendon Sheath Synovial Fluid in Horses. In: Veterinary Surgery 36 (1), 57–63.
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