Using a partially randomized crossover study, levetiracetam (30 mg/kg) was administered intravenously (IV) and orally (PO) as extended release preparation with or without food.
Blood was collected for 24 hours (IV) or 36 hours (PO).
Serum levetiracetam was quantitated by immunoassay and data were subjected to noncompartmental analysis.
Pharmacokinetic parameters for fasted versus fed animals, respectively, were (mean ± SEM): Cmax = 26.6 ± 2.38 and 30.7 ± 2.88 μ/mL, Tmax = 204.3 ± 18.9 and 393.8 ± 36.6 minutes, t1/2 = 4.95 ± 0.55 and 4.48 ± 0.48 hours, MRT = 9.8 ± 0.72 and 10 ± 0.64 hours, MAT = 4.7 ± 0.38 and 5.6 ± 0.67 hours, and F = 1.04 ± 0.04 and 1.26 ± 0.07%.
Significant differences were limited to Tmax (longer) and F (greater) in fed compared to fasted animals.
Serum levetiracetam concentration remained above 5 μ/mL for approximately 20 hours in both fasted and fed animals.
Extended release levetiracetam (30 mg/kg q12h), with or without food, should maintain concentrations above the recommended minimum human therapeutic concentration.
Source: Beasley, M.J. and Boothe, D.M. (2015), Disposition of Extended Release Levetiracetam in Normal Healthy Dogs After Single Oral Dosing. Journal of Veterinary Internal Medicine, 29: 1348–1353. doi: 10.1111/jvim.13588
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