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Meningoencephalitis tuberculosa resembling BSE in a Holstein cow
A very interesting case report has recently been published by a Turkish colleague: A 4 year-old Holstein cow showing clinical signs of BSE did suffer from tuberculosis, as the pathologists were able to prove.

The gross and histopathologic lesions of meningoencephalitis tuberculosa in a 4-year-old Holstein cow showing clinical signs compatible with bovine spongiform encephalopathy are described in this report.

Grossly, numerous gray to yellow, firm and caseous nodules were seen on the ventral surfaces of the brain and in the lateral and fourth ventricles.

Histopathologically, foci of caseation and dystrophic mineralization were surrounded by multinucleated giant cells, epitheloid macrophages, plasma cells, lymphocytes and fibrous proliferation.

Ziehl-Neelsen stains of the lesions revealed masses of slender acid-fast bacilli in the necrotic centers of lesions and within surrounding giant cells.



Source: E. OruÇ (2005): Meningoencephalitis Tuberculosa in a Holstein Cow. In: Vet Pathol 42:856-858 (2005)



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BOVINE

Milk/plasma ratio and milk and plasma pharmacokinetics of amoxicillin in lactating cowsmembers
This study was conducted to determine the passage ratio of amoxicillin into milk and its pharmacokinetics in milk and plasma after intramuscular administration. Five healthy dairy cows (Holstein, weighing 450–500 kg, aged 2–4 years) were used in this study. They received single intramuscular amoxicillin at a dose of 14 mg/kg body weight.

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