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PK and PK/PD of doxycycline in drinking water of pigs
Doxycycline is a popular antibiotic very effective against the most porcine bacterial pathogens like Pasteurella, Mycoplasma etc. It can also be administered via drinking water. But does it reach a sufficient plasma concentration in all animals? An important question!

A commercial doxycycline formulation was administered in drinking water to 12 pigs at the recommended dose of 10 mg/kg daily for 5 days.

The mean plasma concentration at steady-state was 1.37 ± 1.21 μg/mL, which was reached at 68 ± 27.2 h postadministration.

Absorption and elimination half-life values were 7.20 ± 2.42 and 7.01 ± 2.10 h, respectively.

Most plasma concentrations during dosing were higher than the minimum inhibitory concentrations (MICs) described for the main porcine bacterial pathogens of the respiratory tract (Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica and Mycoplasma hyopneumoniae).

It is concluded that when pigs were treated with doxycycline in drinking water at the recommended rate, therapeutically effective concentrations were achieved throughout the treatment period, supporting the clinical use of this tetracycline in the control of respiratory infections. However, inter-animal differences were marked.


Source: PRATS, C., EL KORCHI, G., GIRALT, M., CRISTÒFOL, C., PEÑA, J., ZORRILLA, I., SABORIT, J. & PÉREZ, B. (2005): PK and PK/PD of doxycycline in drinking water after therapeutic use in pigs. In: Journal of Veterinary Pharmacology & Therapeutics 28 (6), 525-530.






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SWINE PRACTICE

Beta hydroxy beta methyl butyrate and the muscle fibre composition in growing pigsmembers
The aim of this recently online published study was to investigate the effects of excess leucine (Leu) vs. its metabolites α‐ketoisocaproate (KIC) and β‐hydroxy‐β‐methyl butyrate (HMB) on Leu metabolism, muscle fibre composition and muscle growth in growing pigs. Thirty‐two pigs with a similar initial weight (9.55 ± 0.19 kg) were fed 1 of 4 diets for 45 days: basal diet, basal diet + 1.25% L‐Leu, basal diet + 1.25% KIC‐Ca, basal diet + 0.62% HMB‐Ca. The results are very promising!

  • L-carnitine as a feed additive in pigs and poultrymembers
  • PCV-3 in pig serum samples from Spainmembers
  • Oral fluid and plasma oxytetracycline concentrations after i.m. administration in pigsmembers
  • Novel highly pathogenic porcine reproductive and respiratory syndrome virus in Chinamembers
  • Calibration of the TonoVet and Tono-Pen Vet tonometers in pigs´ eyesmembers
  • Measurement of serum cobalamin and folate concentrations in pigs with commercially assaysmembers
  • Commercially available immunoassays for serum cobalamin and folate in pigsmembers
  • Ultrasound-guided vessel catheterization in adult pigsmembers
  • Association between porcine cytomegalovirus infection and PMWSmembers
  • Suitable antibiotic therapy to treat swine brucellosismembers
  • Pancuronium versus vecuronium in pigs members
  • Haemodynamic effects of pancuronium and vecuronium in pigsmembers


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