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PK and PK/PD of doxycycline in drinking water of pigs
Doxycycline is a popular antibiotic very effective against the most porcine bacterial pathogens like Pasteurella, Mycoplasma etc. It can also be administered via drinking water. But does it reach a sufficient plasma concentration in all animals? An important question!

A commercial doxycycline formulation was administered in drinking water to 12 pigs at the recommended dose of 10 mg/kg daily for 5 days.

The mean plasma concentration at steady-state was 1.37 ± 1.21 μg/mL, which was reached at 68 ± 27.2 h postadministration.

Absorption and elimination half-life values were 7.20 ± 2.42 and 7.01 ± 2.10 h, respectively.

Most plasma concentrations during dosing were higher than the minimum inhibitory concentrations (MICs) described for the main porcine bacterial pathogens of the respiratory tract (Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica and Mycoplasma hyopneumoniae).

It is concluded that when pigs were treated with doxycycline in drinking water at the recommended rate, therapeutically effective concentrations were achieved throughout the treatment period, supporting the clinical use of this tetracycline in the control of respiratory infections. However, inter-animal differences were marked.


Source: PRATS, C., EL KORCHI, G., GIRALT, M., CRISTÒFOL, C., PEÑA, J., ZORRILLA, I., SABORIT, J. & PÉREZ, B. (2005): PK and PK/PD of doxycycline in drinking water after therapeutic use in pigs. In: Journal of Veterinary Pharmacology & Therapeutics 28 (6), 525-530.






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SWINE PRACTICE

Oral fluid and plasma oxytetracycline concentrations after i.m. administration in pigsmembers
The penetration of oxytetracycline (OTC) into the oral fluid and plasma of pigs and correlation between oral fluid and plasma were evaluated after a single intramuscular (i.m.) dose of 20 mg/kg body weight of long-acting formulation. An important study regarding one of the most popular long-acting antibiotics in pigs.

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