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Iatrogenic induced hermaphroditism in six female littermates
An interesting experiment was undertaken in Belgium: Synthetic androgens were given to a pregnant bitch and the six female puppies developed true hermaphroditism...

A pregnant bitch was treated with a synthetic testosterone mixture on approximately day 40.

The female offspring (six pups) showed an increased anogenital distance, vaginal enlargement and a variable amount of vaginal discharge.

The urinary orifice was found dorsally in the vestibulum, stooled on a protruding phallus-like structure.

All six pups underwent a laparotomy and subsequent spaying and a modified ventral episioplasty technique to lift up the labia to a more vertical position in order to prevent urine accumulation.

Histopathological examination of the genital tracts demonstrated the presence of bilateral ovotestis and remnants of the Wolffian duct system in all cases.

The finding of true hermaphroditism of the offspring after exogenous androgen administration during gestation of the bitch has not yet been reported elsewhere.

Source: Rooster, H, Vercauteren, G, Görtz, K, Saunders, J, Polis, I & Rijsselaere, T (2006): True Hermaphroditism in Six Female Littermates After Administration of Synthetic Androgens to a Pregnant Bitch. In: Reproduction in Domestic Animals 41 (1), 22-26.





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SMALL ANIMAL PRACTICE

Radioactive iodine uptake in hyperthyroid cats after rh-TSHmembers
Radioactive iodine therapy is considered the treatment of choice for hyperthyroidism in cats, but the availability of this modality is limited by costs and hospitalization requirements. Administration of recombinant human thyroid stimulating hormone (rh‐TSH) to humans with thyroid neoplasia or nodular goiter can increase thyroidal iodine uptake, thereby allowing the use of lower radioactive iodine doses for treatment. Veterinary studies of this subject are limited, and results are conflicting. Thus, the objective of this study was to investigate the effects of rh‐TSH administration on thyroidal iodine uptake in hyperthyroid cats.

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