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Chronic wasting disease - new insights
Chronic wasting disease (CWD) remains a unique transmissible spongiform encephalopathy (TSE) of mule deer (Odocoileus hemionus), white-tailed deer (O. virginianus), and Rocky Mountain elk (Cervus elaphus nelsoni). Very interesting new insights from the pathologists´point of view.

The natural history of CWD is incompletely understood, but it differs from scrapie and bovine spongiform encephalopathy (BSE) by virtue of its occurrence in nondomestic and free-ranging species.

CWD has many features in common with scrapie, including early widespread distribution of disease-associated prion protein (PrPd) in lymphoid tissues, with later involvement of central nervous system (CNS) and peripheral tissues.

This distribution likely contributes to apparent efficiency of horizontal transmission and, in this, is similar to scrapie and differs from BSE. Clinical features and lesions of CWD are qualitatively similar to the other animal TSEs.

Microscopically, marked spongiform lesions occur in the central nervous system (CNS) after a prolonged incubation period and variable course of clinical disease.

During incubation, PrPd can be identified in tissues by antibody-based detection systems.

Although CWD can be transmitted by intracerebral inoculation to cattle, sheep, and goats, ongoing studies have not demonstrated that domestic livestock are susceptible via oral exposure, the presumed natural route of exposure to TSEs.

Surveillance efforts for CWD in captive and free-ranging cervids will continue in concert with similar activities for scrapie and BSE.

Eradication of CWD in farmed cervids is the goal of state, federal, and industry programs, but eradication of CWD from free-ranging populations of cervids is unlikely with currently available management techniques.


Source: E. S. Williams (2005): Chronic Wasting Disease. In: Vet Pathol 42:530-549 (2005)



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BOVINE

Subclinical ketosis in dairy cows: prevalence and risk factorsmembers
Subclinical ketosis is commonly seen especially in dairy cows and grazing systems aand can become a serious and sometimes life threatening metabolic problem. The purpose of this study was to estimate the prevalence of Subclinical ketosis (SCK) between 4 and 19 days in milk (DIM) in a grazing production system and investigate the importance of potential risk factors for SCK.

  • Metabolic profiles of cow`s bloodmembers
  • A novel ovine astrovirus associated with encephalitis and ganglionitismembers
  • Pharmacokinetics of an injectable long-acting praziquantel suspension in cattlemembers
  • Tulathromycin versus tildipirosin in experimental Mycoplasma bovis infection in calvesmembers
  • Tulathromycin versus tildipirosin in experimental Mycoplasma bovis infection in calvesmembers
  • Antibodies to bovine viral diarrhoea virus (BVDV) in water buffalo and cattle in Australiamembers
  • Postpartum anoestrus in seasonally-calving dairy farms members
  • Long-term Effects of Pyrethrin and Cyfluthrin on Bull Reproductive Parametersmembers
  • Arthroscopy of the bovine antebrachiocarpal and middle carpal jointmembers
  • Degree of corneal anaesthesia after topical application of various drugsmembers
  • Improvement of the outcome in recumbent dairy cattlemembers
  • Secondary damage in downer cows - an underestimated problemmembers


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