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Compounded omeprazole in treatment of equine gastric ulcers
A study of the University of California, Davis, evaluated the efficacy of compounded omeprazole purchased from a private U.S. pharmacy to Gastrogard®, an FDA-registered formulation of the drug manufactured by Merial Ltd. in 32 horses with gastric ulcers.


`The compounded omeprazole we evaluated was not equivalent to the FDA-approved formulation,` says lead investigator Jack Snyder, DVM, Ph.D., chief of equine lameness and surgery at UC Davis. `It did not effectively lower gastric ulcers scores or resolve gastric lesions.

`The bottom line is that veterinarians, trainers and horse owners need to be very careful when buying any product that is not regulated, because they might not be getting what they asked for,` adds Snyder.

The study used 32 thoroughbred horses that were examined with an endoscope and identified as having significant gastric ulceration.

Endoscopic examinations after 30 days and 60 days of treatment showed that compounded omeprazole neither significantly decreased ulcer severity scores nor aided in preventing the recurrence of ulcers, while Gastrogard was shown to be highly effective, according to researchers.

Of the horses treated first with Gastrogard for 30 days, endoscopic exams showed that all 16 horses had drastically reduced ulcer severity scores, Snyder reports. When those horses were treated with compounded product for the next 30 days, the ulcers returned.

Conversely, of the horses treated first with compounded omeprazole, endoscopic exams after 30 days of treatment showed the compounded product did not significantly reduce ulcer severity scores. When those horses were treated with Gastrogard for the remaining 30 days, all 16 horses had significantly reduced ulcer scores, researchers note.

Source: dvmnewsmagazine.com




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EQUINE

Trema micrantha-associated neurotoxicosis
Trema micrantha is a tree widely distributed throughout the Americas. The tree produces highly palatable leaves that have been associated with natural poisoning in goats, sheep and horses, in which hepatic necrosis and hepatic encephalopathy have been observed.This retrospective case series describes malacia and haemorrhage in the central nervous system (CNS) due to T. micrantha consumption, with minimal to absent hepatic lesions.

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