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Recombinant canine interferon-alpha (KT-100) versus antihistamines in atopic dogs
Various treatments are described in canine atopic dermatitis. Is the innovative therapy with recombinant interferon-gamma an alternative to diphenhydramine, one of the most popular antihistamines? A very interesting study from Japan.

Recombinant canine interferon-ã (KT-100) or topical antihistamine (diphenhydramine: DH) was administered to dogs with atopic dermatitis (AD) for 4 weeks and their efficacies were compared using pruritus, excoriation, erythema and alopecia as evaluation criteria.

Clinical studies on 92 atopic dogs (KT-100 group: 63, DH group: 29) were conducted at 18 animal hospitals in Japan.

KT-100 was administered subcutaneously once a day three times a week on alternating days for 4 weeks.

DH was administered topically twice daily for 4 weeks.

The efficacy rates of the KT-100 group on day 28 were 72.1% for pruritus, 73.8% for excoriation, 75.4% for erythema and 60.7% for alopecia, which were significantly higher than those of the DH group (20.7% for pruritus, 27.6% for excoriation, 24.1% for erythema and 24.1% for alopecia).



Source: Iwasaki, Toshiroh & Hasegawa, Atsuhiko (2006): A randomized comparative clinical trial of recombinant canine interferon-ã (KT-100) in atopic dogs using antihistamine as control. In: Veterinary Dermatology 17 (3), 195-200.




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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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