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Recombinant canine interferon-alpha (KT-100) versus antihistamines in atopic dogs
Various treatments are described in canine atopic dermatitis. Is the innovative therapy with recombinant interferon-gamma an alternative to diphenhydramine, one of the most popular antihistamines? A very interesting study from Japan.

Recombinant canine interferon-ã (KT-100) or topical antihistamine (diphenhydramine: DH) was administered to dogs with atopic dermatitis (AD) for 4 weeks and their efficacies were compared using pruritus, excoriation, erythema and alopecia as evaluation criteria.

Clinical studies on 92 atopic dogs (KT-100 group: 63, DH group: 29) were conducted at 18 animal hospitals in Japan.

KT-100 was administered subcutaneously once a day three times a week on alternating days for 4 weeks.

DH was administered topically twice daily for 4 weeks.

The efficacy rates of the KT-100 group on day 28 were 72.1% for pruritus, 73.8% for excoriation, 75.4% for erythema and 60.7% for alopecia, which were significantly higher than those of the DH group (20.7% for pruritus, 27.6% for excoriation, 24.1% for erythema and 24.1% for alopecia).



Source: Iwasaki, Toshiroh & Hasegawa, Atsuhiko (2006): A randomized comparative clinical trial of recombinant canine interferon-ã (KT-100) in atopic dogs using antihistamine as control. In: Veterinary Dermatology 17 (3), 195-200.




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SMALL ANIMAL PRACTICE

Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a Persian cat
A 10‐year‐old male neutered Persian cat was presented with an abdominal mass and history of weakness. Blood smear examination found marked elliptocytosis, and serum biochemical analysis revealed hypokalemia, hypochloremia, increased creatine kinase activity, and a high aldosterone concentration. Cytologic examination of the mass revealed neoplastic endocrine cells with moderate criteria of malignancy, favoring adrenocortical neoplasia. A very interesting case report!

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