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Successful therapy with recombinant canine oral papillomavirus vaccine (Case report)
Oral papillomatosis is a well-known condition especially in younger dogs. Most cases show a spontaneous resolution over a few month time. This case report describes a persistent and surgery-refractory case in a dog that finally was treated with the vaccine.

This report describes a 16-month-old female, otherwise seemingly healthy, Siberian husky dog with severe oral papillomatosis that did not regress spontaneously and was refractory to surgical treatment over a 6-month period.

Regression of the papillomas was achieved by administering a series of experimental vaccinations starting at the time of the last surgery. The vaccine consisted of systemically administered canine oral papillomavirus major coat protein L1 that has been shown to self-assemble into virus-like particles. They cause a humoral response that has been shown to prevent the onset and development of papillomas.

In this case, however, following unsuccessful surgical treatment, the vaccine acted therapeutically, causing the papillomas that had regrown to shrink. No side-effects were noted.

Source: Kuntsi-Vaattovaara, H., Verstraete, F. J. M., Newsome, J. T. & Yuan, H. (2003): Resolution of persistent oral papillomatosis in a dog after treatment with a recombinant canine oral papillomavirus vaccine. In: Veterinary and Comparative Oncology 1 (1), pp 57-63

Foto: Dr. Stefanie Peters, Birkenfeld





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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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