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Successful therapy with recombinant canine oral papillomavirus vaccine (Case report)
Oral papillomatosis is a well-known condition especially in younger dogs. Most cases show a spontaneous resolution over a few month time. This case report describes a persistent and surgery-refractory case in a dog that finally was treated with the vaccine.

This report describes a 16-month-old female, otherwise seemingly healthy, Siberian husky dog with severe oral papillomatosis that did not regress spontaneously and was refractory to surgical treatment over a 6-month period.

Regression of the papillomas was achieved by administering a series of experimental vaccinations starting at the time of the last surgery. The vaccine consisted of systemically administered canine oral papillomavirus major coat protein L1 that has been shown to self-assemble into virus-like particles. They cause a humoral response that has been shown to prevent the onset and development of papillomas.

In this case, however, following unsuccessful surgical treatment, the vaccine acted therapeutically, causing the papillomas that had regrown to shrink. No side-effects were noted.

Source: Kuntsi-Vaattovaara, H., Verstraete, F. J. M., Newsome, J. T. & Yuan, H. (2003): Resolution of persistent oral papillomatosis in a dog after treatment with a recombinant canine oral papillomavirus vaccine. In: Veterinary and Comparative Oncology 1 (1), pp 57-63

Foto: Dr. Stefanie Peters, Birkenfeld





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SMALL ANIMAL PRACTICE

Microbiota of traumatic, open fracture wounds and the mechanism of injury
Open fractures are characterized by disruption of the skin and soft tissue, which allows for microbial contamination and colonization. Preventing infection‐related complications of open fractures and other acute wounds remains an evolving challenge due to an incomplete understanding of how microbial colonization and contamination influence healing and outcomes. Culture‐independent molecular methods are now widely used to study human‐associated microbial communities without introducing culture biases. This recently online published study describes the fascinating association between the mechanism of injury and the microbiota of the wounds.

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