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Incidence of Polysaccharide Storage Myopathy in Horses
Polysaccharide storage myopathy is commonly seen in some horse breeds and is a very serious incurable disease. This large study including muscle samples of more than 200 horses gives interesting informations about the incidence of this disease, especially in certain horse breeds.

Muscle samples were obtained at necropsy from 225 horses and ponies 1 year of age or older. Samples were processed in routine manner and were stained with hematoxylin and eosin and with periodic acid-Schiff for glycogen.

Sections were examined for abnormal glycogen content and amylase-resistant complex polysaccharide and for chronic myopathic change (excessive fiber size variation, increase in number of internal nuclei).

A total of 101 horses and ponies with lesions of polysaccharide storage myopathy were identified.

Age of affected horses ranged from one to 30 years, with a mean of 14.7 years. Mean age of nonaffected horses was 12 years.

Incidence of polysaccharide storage myopathy varied depending on breed; Thoroughbreds had the lowest (27%) and draft-related horses had the highest (86%) incidence.

Chronic myopathic changes were more severe in polysaccharide storage myopathy-affected horses than in nonaffected horses.

Results of this study indicate that polysaccharide storage myopathy is a common disorder of many breeds of horses and ponies.




Source: B. A. Valentine and B. J. Cooper (2005): Incidence of Polysaccharide Storage Myopathy: Necropsy Study of 225 Horses. In: Vet Pathol 42:823-827 (2005)



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EQUINE

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