Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Privacy Policy  
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Chemotherapy plus half-body radiation therapy for canine lymphoma
The combination of radiotherapy and chemotherapy is commonly used in human medicine: The radiotherapy mainly is thought to decrease the size of the primary tumor, chemotherapy mainly acts against metastases. It is not a common combination in one of the most common canine malignant tumors, malignant lymphoma. Is it an indication for this therapy? A very interesting study including nearly 100 dogs.

A protocol of induction chemotherapy followed by half-body radiation therapy for treatment of lymphoma was used in 94 dogs.
Seventy-three (78%) dogs achieved complete remission.
Substage (P = .011) and phenotype (P = .015) were identified as predictors of complete remission rate.

Of these, 52 dogs received half-body irradiation. Cranial and caudal halves received a total dose of 8.0 Gy, given in 2 fractions of 4.0 Gy on consecutive days with cobalt-60 photons and a 3-week interval between halves.

Median 1st remission for these dogs was 311 days. Anemia was identified as the only predictor for length of 1st remission (P = .024).

Toxicoses after half-body irradiation generally were mild and infrequent and included myelosuppression and gastrointestinal signs.

Thirty-one dogs relapsed and 20 resumed treatment with induction followed by maintenance chemotherapy.

Seventeen (85%) dogs achieved a 2nd complete remission.

Median overall remission for all 52 dogs was 486 days.

Results of this study suggest that half-body radiation therapy after induction chemotherapy is well tolerated and might increase remission duration compared with conventional protocols that use chemotherapy alone, but this increase might not be long enough to be clinically relevant or to justify application of the method described herein.



Source: Williams LE, Johnson JL, Hauck ML, Ruslander DM, Price GS, Thrall DE. (2004): Chemotherapy followed by half-body radiation therapy for canine lymphoma. In: J Vet Intern Med. 2004 Sep-Oct;18(5):703-9.




Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Radioactive iodine uptake in hyperthyroid cats after rh-TSHmembers
Radioactive iodine therapy is considered the treatment of choice for hyperthyroidism in cats, but the availability of this modality is limited by costs and hospitalization requirements. Administration of recombinant human thyroid stimulating hormone (rh‐TSH) to humans with thyroid neoplasia or nodular goiter can increase thyroidal iodine uptake, thereby allowing the use of lower radioactive iodine doses for treatment. Veterinary studies of this subject are limited, and results are conflicting. Thus, the objective of this study was to investigate the effects of rh‐TSH administration on thyroidal iodine uptake in hyperthyroid cats.

  • Hypoechoic tissue changes in dogs with malignant prostatic lymphomamembers
  • Emphysematous gastritis in dogs and catsmembers
  • Primary pulmonary histiocytic sarcoma in dogsmembers
  • Determining prognosis in canine sepsis members
  • Correlation of plasma and tear glucose, creatinine and urea nitrogen in catsmembers
  • Perineal hernias in dogs - always a bilateral problem?members
  • Pharmacokinetic of gabapentin in catsmembers
  • Follicular development of canine ovaries stimulated by eCG plus hCGmembers
  • Gastrointestinal effects following acupuncture in healthy dogsmembers
  • Bilateral repair of apparently unilateral perineal hernias in dogsmembers
  • Retinal morphology of canine sudden acquired retinal degeneration syndromemembers
  • Sulfur hexafluoride microbubbles to improve ocular sonography in birdsmembers


  • [ Home ] [ About ] [ Contact / Request ] [ Privacy Policy ]

    Copyright © 2001-2018 VetContact GmbH
    All rights reserved