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Prognostic criteria in canine synovial sarcoma
Canine synovial sarcoma is thought to be a rare condition. If diagnosed, many owners want have precise prognostic informations before they are willing to do any therapy. A retrospective study to describe prognostic criteria was performed in 16 dogs.

Pertinent patient data and biopsied tissue from 16 cases of canine synovial sarcoma (SS) were reviewed. Histopathological grade, clinical stage, and tissue immunoreactivity to cytokeratin (broad stain, AE1/AE3 and cytokeratin 7) and vimentin were determined and correlated with survival. Effect of treatment on survival was similarly evaluated.

Neither clinical stage nor histopathological grade significantly affected survival patterns. Tissues from all cases stained >30% positively with vimentin, whereas no tissue from any case exhibited cytokeratin immunoreactivity. Dogs receiving surgical tumor excision or amputation had a significantly higher survivability than those receiving no treatment (P<0.02). Treatment aggressiveness may be more appropriate than clinical staging or tumor grading in predicting survival.

Reliability of diagnosing and prognosticating canine SS with current immunohistochemistry protocols should be questioned.

Source: DB Fox, JL Cook, JM Kreeger, M Beissenherz, CJ Henry (2002): Canine synovial sarcoma: A retrospective assessment of described prognostic criteria in 16 cases (1994-1999). In:
Journal of the American Animal Hospital Association, 2002, Vol 38, Iss 4, pp 347-355





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SMALL ANIMAL PRACTICE

Patient-specific facemask to facilitate brain biopsymembers
The objective of this pilot study was to describe the application and first preliminary data of a novel MRI and CT compatible patient-specific facemask for stereotactic brain biopsy of intracranial lesions in dogs. Five client-owned dogs presenting for neurological deficits consistent with forebrain disease were included in the study. All dogs had MRI findings consistent with an intracranial lesion. But biopsies in this region are not easy to obtain. Does an individual face mask help?

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