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Prognostic criteria in canine synovial sarcoma
Canine synovial sarcoma is thought to be a rare condition. If diagnosed, many owners want have precise prognostic informations before they are willing to do any therapy. A retrospective study to describe prognostic criteria was performed in 16 dogs.

Pertinent patient data and biopsied tissue from 16 cases of canine synovial sarcoma (SS) were reviewed. Histopathological grade, clinical stage, and tissue immunoreactivity to cytokeratin (broad stain, AE1/AE3 and cytokeratin 7) and vimentin were determined and correlated with survival. Effect of treatment on survival was similarly evaluated.

Neither clinical stage nor histopathological grade significantly affected survival patterns. Tissues from all cases stained >30% positively with vimentin, whereas no tissue from any case exhibited cytokeratin immunoreactivity. Dogs receiving surgical tumor excision or amputation had a significantly higher survivability than those receiving no treatment (P<0.02). Treatment aggressiveness may be more appropriate than clinical staging or tumor grading in predicting survival.

Reliability of diagnosing and prognosticating canine SS with current immunohistochemistry protocols should be questioned.

Source: DB Fox, JL Cook, JM Kreeger, M Beissenherz, CJ Henry (2002): Canine synovial sarcoma: A retrospective assessment of described prognostic criteria in 16 cases (1994-1999). In:
Journal of the American Animal Hospital Association, 2002, Vol 38, Iss 4, pp 347-355





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SMALL ANIMAL PRACTICE

Staining hair samples with a modified Wright-Giemsa stain to diagnose feline dermatophytosismembers
Direct examination of the hair is a simple diagnostic test for the diagnosis of dermatophytosis; training is needed to use this test. This study tried to evaluate whether use of modified Wright–Giemsa blue stain and/or photographic images of infected and uninfected hairs improved the user`s ability to identify infected or uninfected hairs. Ten cats with, and 10 cats without, dermatophytosis due to Microsporum canis (n = 20) were enrolled.

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