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Diuresis and fenoldopam in healthy cats
Diuretics are sometimes indicated in cats and besides the classic furosemide other substances are investigated. What about the effect of an fenoldopam infusion on urine output, sodium excretion, creatinine clearance, and indirect blood pressure in healthy cats? A new prospective study investigates these effects.


Eight purpose-bred cats, 2–4 years old, were included in this study.

Urine output was measured hourly for 12 hours before and after fenoldopam administration. Sodium excretion, modified creatinine clearance, and fractional sodium excretion were measured before and following fenoldopam administration. Urine specific gravity, central venous pressure, and systolic blood pressure were measured every 4 hours during the experiment.

Main results:
Compared with pre-infusion values, urine output, sodium excretion, and fractional excretion of sodium increased significantly 6 hours after initiation of fenoldopam infusion.
This increase was sustained throughout the observation period.

The modified creatinine clearance decreased significantly following 2 hours of fenoldopam infusion, but increased significantly by 6 hours after infusion, the time of peak urine output.

Changes in urine specific gravity mirrored changes in fractional sodium excretion, whereas the central venous pressure mirrored changes in modified creatinine clearance.

The diuretic effect in cats was prevented when a dopamine receptor blocking agent was administered before fenoldopam infusion.


Conclusion:
Fenoldopam at a dose of 0.5 ìg/kg/min induces diuresis in cats in a delayed manner. This increase appears to be due, in part, to dopamine receptor-induced natriuresis. Changes in glomerular filtration rate may also occur.


Source: Jeffery P Simmons, James S Wohl, Dean D Schwartz, Heather G Edwards, James C Wright (2006): Diuretic effects of fenoldopam in healthy cats. In: Journal of Veterinary Emergency and Critical Care 16 (2), 96–103.



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