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Reevaluation of the 2-Year Protocol for Treating Canine Lymphosarcoma
Canine lymphosarcomas are common neoplasias which tend to respond very well to chemotherapy. Various treatment protocols are used worldwide, and the 2-year-protocol of the University of Wisconsin is a common one. This interesting study reevaluates the data of nearly 100 dogs...

This retrospective study investigated a population of 96 dogs with newly diagnosed malignant lymphosarcoma that were treated with the commonly used University of Wisconsin-Madison (UW-M) chemotherapy protocol.

Pretreatment characteristics were analyzed to determine prognostic factors.

Dogs with higher World Health Organization (WHO) stages (including stage IV) and dogs with hypercalcemia were at significantly higher risk of relapse (P=0.018 and P=0.016, respectively).

Dose reduction, treatment delays, and prior therapy with cortico-steroids were not associated with clinical outcome.
First remission duration of 270 days was similar to historically reported data.

Overall survival time of 218 days was much shorter than historical data.



Source: Claire Inderbinen Kaiser, Janean L. Fidel, Malgorzata Roos, Barbara Kaser-Hotz (2007): Reevaluation of the University of Wisconsin 2-Year Protocol for Treating Canine Lymphosarcoma. In: Journal of the American Animal Hospital Association 43:85-92 (2007)





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SMALL ANIMAL PRACTICE

Variability of SDMA in apparently healthy dogsmembers
Symmetric dimethylarginine (SDMA) is a screening tool for early kidney dysfunction and monitoring treatment in cases of chronic kidney disease (CKD). There are no current studies describing the suitability of this test for use with published population‐based reference intervals. The objectives of this study were to determine the components of biological variability, the index of individuality (IOI), the critical difference between sequential measurements (CD) and the number of measurements required to assess the homeostatic set point (HSP), for both SDMA and serum creatinine (sCr), in apparently healthy dogs.

  • Bioavailability of suppository acetaminophen in dogsmembers
  • Computed tomographic lymphography for lymph node staging in dogs with malignant tumors members
  • Characterization of ocular melanosis-affected canine melanocytesmembers
  • Nasopharyngeal sialoceles in brachycephalic dogsmembers
  • Enterococcus faecium SF68 on serum cobalamin and folate concentrationsmembers
  • Gastrointestinal eosinophilic sclerosing fibroplasia limited to the mesentery in a catmembers
  • Ion acid-base disturbances and associated mortality in dogsmembers
  • First description of ultrasonic bone curette in canine otic surgerymembers
  • Staining hair samples with a modified Wright-Giemsa stain to diagnose feline dermatophytosismembers
  • Oral extended release hydrocodone as analgesia after TPLOmembers
  • 25OH vitamin D3 serum concentration in dogs with acute polyradiculoneuritismembers
  • Type 1 immune mediated polyarthritis in dogs and temporal relationship to vaccination members


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