Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

deutsch english español polski franç

start search
Home / WELCOME / Archiv / Bovine /  
 
Use of bovine LH-R to reach reversible infertility in bitches
Reversible infertility is commonly wanted by dog owners who are not willing to have their dogs castrated. Routinely, this effect is reached by the use of gestagens, but their side effects can be serious. Scientists investigated if bovine LH-R injections could be used for the same purpose.

Adult female dogs were immunized with 0.5 mg bovine luteinizing hormone receptor (LH-R) encapsulated in a silastic subdermal implant and subsequently with four intramuscular booster injections of 0.1 mg LH-R each. Circulating LH-R antibody was detected in the sera 3 weeks post-implant.

The appearance of LH-R antibody was associated with a decline in the serum progesterone concentrations to a range of 0-0.5 ng/ml until day 365 in the immunized dogs in comparison with a range of 5-10 ng in the control animals, suggesting a lack of ovulation and corpus luteum function in immunized dogs. The immunized dogs did not show signs of `standing heat` and failed to ovulate when induced by LH-RH challenge. Serum oestradiol levels, however, remained in the range of 30-40 pg/ml in both the immunized and the control dogs.
With the decline in the antibody titres, the hormonal profile and vaginal cytology returned to a fertile state and the dogs exhibited signs of `standing heat`, as well as vaginal bleeding. Dogs immunized with LH-R did not show any serious metabolic, local or systemic adverse effects. The hypothalamic-pituitary gonadal axis remained intact as indicated by little difference in pituitary LH levels between control and immunized animals, and by the release of LH by LH-RH challenge.

These studies demonstrate that active immunization of female dogs with LH-R could immunomodulate ovarian function to cause a reversible state of infertility. It may be postulated that, due to extensive interspecies homology, a recombinant LH receptor-based immunocontraceptive vaccine may also be effective in other vertebrates.

Source: BB Saxena, A Clavio, M Singh, P Rathnam, Y Bukharovich, T Reimers Jr, A Saxena,S Perkins (2002): Modulation of Ovarian Function in Female Dogs Immunized with Bovine Luteinizing Hormone Receptor. In: Reproduction in Domestic Animals Volume 37 Issue 1 Page 9 - February 2002




Tell a friend   |   Print version   |   Send this article

BOVINE

A novel ovine astrovirus associated with encephalitis and ganglionitismembers
In June 2013, a 4-year-old Welsh Mountain ewe and in March 2014 a 10-day-old lamb of the same breed and the same flock presented progressive neurological signs including depressed sensorium, tremor, and unusual behaviour. Neuropathological examination of the brain and spinal cord detected non-suppurative polioencephalomyelitis and dorsal root ganglionitis, characteristic of a neurotropic viral agent in both sheep. Which agent is this?

  • Pharmacokinetics of an injectable long-acting praziquantel suspension in cattlemembers
  • Tulathromycin versus tildipirosin in experimental Mycoplasma bovis infection in calvesmembers
  • Tulathromycin versus tildipirosin in experimental Mycoplasma bovis infection in calvesmembers
  • Antibodies to bovine viral diarrhoea virus (BVDV) in water buffalo and cattle in Australiamembers
  • Postpartum anoestrus in seasonally-calving dairy farms members
  • Long-term Effects of Pyrethrin and Cyfluthrin on Bull Reproductive Parametersmembers
  • Arthroscopy of the bovine antebrachiocarpal and middle carpal jointmembers
  • Degree of corneal anaesthesia after topical application of various drugsmembers
  • Improvement of the outcome in recumbent dairy cattlemembers
  • Secondary damage in downer cows - an underestimated problemmembers
  • Regulation of Anti-Muellerian Hormone in Cattlemembers
  • Concentration of potassium in different tissues of cows with anorexy and ileusmembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved