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Survival time in dogs with non-treated nasal carcinomas
Not all owners of dogs with malignant nasal tumors agree to perform surgery, radiation or chemotherapy. Less is known about the survival time of dogs receiving no or only palliative therapy. A large and very informative study provides more informations to give to the owners of affected dogs.

the objective of the retrospective study was to evaluate factors associated with survival in dogs with nasal carcinomas that did not receive treatment or received only palliative treatment. 139 dogs with histologically confirmed nasal carcinomas were included.

Medical records, computed tomography images, and biopsy specimens of nasal carcinomas were reviewed.

Only dogs that were not treated with radiation, surgery, chemotherapy, or immunotherapy and that survived > or = 7 days from the date of diagnosis were included.

The Kaplan-Meier method was used to estimate survival time.

Factors potentially associated with survival were compared by use of log-rank and Wilcoxon rank sum tests.

Multivariable survival analysis was performed by use of the Cox proportional hazards regression model.

RESULTS: Overall median survival time was 95 days (95% confidence interval [CI], 73 to 113 days; range, 7 to 1,114 days). In dogs with epistaxis, the hazard of dying was 2.3 times that of dogs that did not have epistaxis.

Median survival time of 107 dogs with epistaxis was 88 days (95% CI, 65 to 106 days) and that of 32 dogs without epistaxis was 224 days (95% CI, 54 to 467 days).

CONCLUSIONS AND CLINICAL RELEVANCE: The prognosis of dogs with untreated nasal carcinomas is poor. Treatment strategies to improve outcome should be pursued.



Source: Rassnick KM, et al (2006): Evaluation of factors associated with survival in dogs with untreated nasal carcinomas: 139 cases (1993-2003). In: J Am Vet Med Assoc. 2006 Aug 1;229(3):401-6.




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SMALL ANIMAL PRACTICE

Long-term compassionate use of oclacitinib in dogs with allergic skin disease
Oclacitinib is safe and effective for treating dogs with pruritus associated with allergic and atopic dermatitis, based on randomized clinical trials of up to 4 months duration. But unfortunately, allergic diseases currently can be managed but not cured, and in most cases a long-term therapy is indicated. This study assessed long-term safety, efficacy and quality of life of oclacitinib-treated dogs enrolled in a compassionate use programme including nearly 250 dogs.

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