Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinšr
Tiermedizin
  WELCOME  
vetcontact
Vetrinšr
Tiermedizin
  Privacy Policy  
  Home  
  Login / Newsletter  
vetcontact
Vetrinšr
Tiermedizin
  CONTACTS  
vetcontact
Vetrinšr
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinšr
Tiermedizin
  PROFESSION  
vetcontact
Vetrinšr
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinšr
Tiermedizin
  INSIGHT  
vetcontact
Vetrinšr
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinšr
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinšr
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english espaŮol polski francais
Home / WELCOME / Archiv / Swine Practice /     
 
Viscoelastic properties of lungs and thoracic wall of anesthetized piglets
An interesting study was performed in six anesthetized mechanically ventilated piglets weighting 30 kg. The viscoelastic properties of lungs and thoracic wall were investigated and serve as a viscoelastic model.

Animals were tracheotomized, anesthetized and mechanically ventilated under controlled conditions.

After control measurements of the mechanical properties of the lung of the pigs had been taken, acute lung injury (ALI) was induced by saline lavage. Lung and thoracic wall tissue resistance (¦¤R), which reflects viscoelastic properties and/or time constant inequalities, were determined by using a rapid airway occlusion technique during constant flow inflation ( ), at constant tidal volume. was varied from 0.1¨C0.2 to 1.2 L second1 on a single breath.

Multiple data sets of ¬¶¬§R of lung (¬¶¬§RL) and thoracic wall (¬¶¬§Rw) to inspiratory time (TI = VT/ ) were fitted to a model whose prediction equation was ¬¶¬§R = R2[1 −exp(−TI/¬¶√ď2)], where R2 and ¬¶√ď2 are the ¬°¬ģviscoelastic¬°¬Į resistance and time constant, respectively.

Subscripts L and W are used to represent lung and theracic wall, respectively (R2L, R2W, ¬¶√ď2L, ¬¶√ď2W).

Two more sets of physiological measurements were then taken ¨C the first under zero end-expiratory pressure (ZEEP) and the second under a positive end-expiratory pressure (PEEP) of 10 cmH2O.

Results: Data of ¬¶¬§R adequately fitted to the prediction equation in all instances. In control, R2,L was 15.3 (10.7¬®C22.6) cmH2O L1 second1 (median, interquartile range), ¬¶√ď2,L 3.3 (1.9¬®C5.5) seconds, R2,w 6.5 (2.2¬®C10.3) cmH2O L1 second1 and ¬¶√ď2,w 2.9 (1.1¬®C4.3) seconds.

In ALI, R2,L significantly increased to 129.6 (105.9¨C171.3) cmH2O L1 second1 on ZEEP but not significantly decreased to 48.9 (17.8¨C109.6) cmH2O L1 second1 with PEEP.

The corresponding values of ¬¶√ď2,L were 7.1 (5.1¬®C11.6) and 4.4 (3.1¬®C5.5) seconds. The values pertaining to thoracic wall did not change significantly among conditions.

Conclusions and clinical relevance: Viscoelastic properties of the lung and thoracic wall in piglets can be described by a viscoelastic model. Values of parameters of this model were markedly increased in ALI and decreased with PEEP.



Source: Claude Gu¨¦rin, Fr¨¦d¨¦rique Bayle, Sophie Debord, Jean-Charles Poupelin, Michel Badet, St¨¦phane Lemasson, Jean-Christophe Richard (2007): Viscoelastic properties of lungs and thoracic wall of anesthetized mechanically ventilated piglets. In: Veterinary Anaesthesia and Analgesia 34 (5), 331¨C338.



Tell a friend   |   Print version   |   Send this article

SWINE PRACTICE

Pasteurella multocida diversity in poultry and pigs in Australiamembers
This recently published study investigates the genotype and diversity of Pasteurella multocida present in pig herds and determines the extent of overlap with isolates from poultry flocks in Australia. Do the isolates vary? A very interesting study not only for Australia.

  • Enrofloxacin and the porcine livermembers
  • Outbreak of PEDV in Italymembers
  • Actinobacillus rossii as cause of abortion in a piglet members
  • Association between genome and aggression in group-housed pigsmembers
  • Oral fluid and plasma oxytetracycline concentrations after intramuscular administration¬†in pigsmembers
  • Pharmacokinetics and behavioral effects of a liquid transdermal fentanyl solution in pigsmembers
  • Beta hydroxy beta methyl butyrate and the muscle fibre composition in growing pigsmembers
  • L-carnitine as a feed additive in pigs and poultrymembers
  • PCV-3 in pig serum samples from Spainmembers
  • Oral fluid and plasma oxytetracycline concentrations after i.m. administration in pigsmembers
  • Novel highly pathogenic porcine reproductive and respiratory syndrome virus in Chinamembers
  • Calibration of the TonoVet and Tono-Pen Vet tonometers in pigs¬ī eyesmembers


  • [ Home ] [ About ] [ Contact / Request ] [ Privacy Policy ]

    Copyright © 2001-2018 VetContact GmbH
    All rights reserved