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Ohio State University creates first DNA gene chip for horses
The chip, a sliver of glass, which houses more than 3,200 horse genes, is the size of a postage stamp. It contains thousands of the genes for a horse and allows researchers to scan an individual horse`s genes to see which are active in certain situations.


As an example, drug companies may use a gene chip to see how a specific drug will affect an animal.

Gene chips already exist for humans, mice, rats and some microorganisms. Scientists say having a representative gene chip for a large animal now could lead to better accuracy in studying human disease.

`Although we rely on animal models to study human diseases, we really aren`t sure what some of the genetic differences are between those animal models and humans,` says Alicia Bertone, researcher, who led OSU`s efforts in develop the equine gene chip. `Gene chips can help us uncover these key differences, giving us critical information before we launch into an experiment.`

Bertone developed the chip with the aid of Weisong Gu, also a researcher at OSU. The work was supported in part by Affymetrix, manufacturer of various gene chips.

Source: `Ohio State debuts first gene chip for horses`. In: DVM Newsmagazine December 22, 2003. www.dvmnewsmagazine.com/dvm/





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EQUINE

Two regimens of lidocaine infusion in horses undergoing laparotomy for colicmembers
Various lidocaine protocols are described for horses undergoing Colic surgery. This interesting prospective, randomized clinical study compares the effects of administering or not administering a loading intravenous (IV) bolus of lidocaine prior to its constant rate infusion (CRI). Effects investigated during isoflurane anaesthesia were end-tidal isoflurane concentration (Fe′ISO), cardiovascular function, anaesthetic stability and the quality of recovery.
Thirty-six client-owned horses were enrolled.

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