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Feline mucinous cholangiocarcinoma (case report)
A marked peritoneal effusion is not always associated with heart failure or viral diseases like FIP, it can also be due to a rare neoplasia like cholangiocarcinoma. A very interesting case report illustrating the difficulties to get to the diagnosis of this rare neoplasia!

Mucinous cholangiocarcinoma was diagnosed in a 14-year-old, castrated male, domestic shorthaired cat with marked peritoneal effusion. Cytological confirmation of malignancy by fluid analysis and fine-needle, ultrasound-guided aspiration of the liver was followed by histological examination of tissue samples obtained at surgery and necropsy. No observed response followed chemotherapy with doxorubicin and carboplatin. Electron microscopy and immunohistochemistry helped to further characterize this unusual tumor.


Source: Terry M. Jacobs, Paul W. Snyder (2007): Mucinous Cholangiocarcinoma in a Cat. In: Journal of the American Animal Hospital Association 43:168-172 (2007)




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SMALL ANIMAL PRACTICE

Variability of SDMA in apparently healthy dogsmembers
Symmetric dimethylarginine (SDMA) is a screening tool for early kidney dysfunction and monitoring treatment in cases of chronic kidney disease (CKD). There are no current studies describing the suitability of this test for use with published population‐based reference intervals. The objectives of this study were to determine the components of biological variability, the index of individuality (IOI), the critical difference between sequential measurements (CD) and the number of measurements required to assess the homeostatic set point (HSP), for both SDMA and serum creatinine (sCr), in apparently healthy dogs.

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