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Radiotherapy and mitoxantrone for anal sac adenocarcinoma in dogs
Anal sac adenocarcinomas (ASAC) are not to common but really malignant tumours. Surgery is the therapy of choice. Do concurrent curative-intent radiotherapy and mitoxantrone (MX) after surgical removal of the primary tumour influence the outcome?

The medical records of 15 dogs with anal sac adenocarcinoma (ASAC) were reviewed retrospectively in this study.

Radiation was prescribed at 15 daily fractions of 3.2 Gy for a total dose of 48 Gy. MX was given intravenously at a dosage of 5 mg m2 every 3 weeks for five treatment sessions. Twelve dogs received pelvic irradiation to include the regional lymph nodes (LNs) and three received radiation only to the perineum. At the time of diagnosis, four dogs were hypercalcaemic and seven dogs presented with regional LN metastasis. All the dogs with regional LN metastasis received pelvic irradiation, and in three cases, metastatic LNs were treated in the macroscopic disease setting.

The median event-free survival was 287 days, and the median overall survival was 956 days.

Acute and chronic radiation complications were common and non-life threatening, although chronic complications contributed to the decision to euthanize two dogs.

The results observed in this retrospective analysis compare favourably with cases of ASAC in the literature related to treatment with surgery and/or chemotherapy.

Source: Turek, M. M., Forrest, L. J., Adams, W. M., Helfand, S. C. & Vail, D. M. (2003): Postoperative radiotherapy and mitoxantrone for anal sac adenocarcinoma in the dog: 15 cases (1991-2001). In: Veterinary and Comparative Oncology 1 (2), 94-104



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