Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
  Interferon  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Cardiomyopathy, arterial thrombembolism and hypercoagulability in cats
Arterial thromboembolism (ATE) is a common complication of feline cardiomyopathy; however, the pathogenesis of ATE is unknown. Is there perhaps a systemic activation of the coagulation cascade (hypercoagulability) in affected cats, and endothelial injury promotes ATE? An interesting hypothesis...


Healthy cats (n = 30) and 3 groups of cardiomyopathic cats: Group (1) left atrial enlargement only (LAE [n = 11]), ie, left atrial to aortic ratio >1.4; Group (2) LAE with spontaneous echocardiographic contrast, atrial thrombi or both (SEC-T [n = 16]); and Group (3) acute ATE with LAE (n = 16).

Methods: Hypercoagulability was defined by 2 or more laboratory abnormalities reflecting coagulation factor excess (high fibrinogen concentration or Factor VIII coagulant activity), inhibitor deficiency (low antithrombin activity), or thrombin generation (high thrombin-antithrombin complex [TAT] and d-dimer concentrations).

High von Willebrand factor antigen concentration (vWF : Ag) was considered a marker of endothelial injury. Data were analyzed using nonparametric statistics.

Results: The 3 groups of cats with cardiac disease had higher median fibrinogen concentrations than did the healthy cats.

Criteria of hypercoagulability were found exclusively in cats with SEC-T (50%) and ATE (56%).

Hypercoagulability was not associated with left atrial size or congestive heart failure (CHF). ATE cats had significantly higher median vWF : Ag concentration than did the other groups.

Conclusions and Clinical Importance: Systemic hypercoagulability is evident in many cardiomyopathic cats, often without concurrent CHF or overt ATE.

Hypercoagulabilty may represent a risk factor for ATE.

High vWF : Ag in ATE cats was attributed to downstream endothelial injury from the occlusive thrombus.


Source: T. Stokol, et al (2008): Hypercoagulability in Cats with Cardiomyopathy. In: Journal of Veterinary Internal Medicine
Volume 22 Issue 3, Pages 546 - 552




Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Symmetric Dimethylarginine Serum Concentration and Glomerular Filtration Rate in Cats
Direct measurement of glomerular filtration rate (GFR) is the preferred method to assess renal function in cats, but it is not widely used in the diagnosis of chronic kidney disease (CKD). In cats with CKD, symmetric dimethylarginine (SDMA) has been shown to increase and to correlate with plasma creatinine concentrations. Does a reduced GFR correspond with increased serum SDMA concentration?

  • Intradermal test reactivity and serum allergen-specific IgE measurement for Malassezia pachydermatismembers
  • Treatment of feline corneal sequestrum (FCS) with corneal graftingmembers
  • Effects of Flexion and Extension on the Diameter of the Canine Caudal Cervical Vertebral Canal members
  • Arthroscopic Treatment of Young Large Breed Dogs With Medial Compartment Disease of the Elbowmembers
  • Topical 1% 5-fluorouracil in a young dog with corneal squamous cell carcinomamembers
  • Perioperative Antimicrobials During Tibial Plateau Leveling Osteotomymembers
  • Serum and urine Blastomyces antigen as markers of clinical remissionmembers
  • Association between vitreous degeneration and cataract in dogsmembers
  • Capsular tension ring use in dogs with phacoemulsification and IOL implantationmembers
  • Minocycline in meticillin-resistant Staphylococcus pseudintermedius infectionsmembers
  • Ultrasound biomicroscopy of the normal canine haired skinmembers
  • Effects of aloe vera on corneal wound closure and collagenase activitymembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2013 VetContact GmbH
    All rights reserved