Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Cardiomyopathy, arterial thrombembolism and hypercoagulability in cats
Arterial thromboembolism (ATE) is a common complication of feline cardiomyopathy; however, the pathogenesis of ATE is unknown. Is there perhaps a systemic activation of the coagulation cascade (hypercoagulability) in affected cats, and endothelial injury promotes ATE? An interesting hypothesis...


Healthy cats (n = 30) and 3 groups of cardiomyopathic cats: Group (1) left atrial enlargement only (LAE [n = 11]), ie, left atrial to aortic ratio >1.4; Group (2) LAE with spontaneous echocardiographic contrast, atrial thrombi or both (SEC-T [n = 16]); and Group (3) acute ATE with LAE (n = 16).

Methods: Hypercoagulability was defined by 2 or more laboratory abnormalities reflecting coagulation factor excess (high fibrinogen concentration or Factor VIII coagulant activity), inhibitor deficiency (low antithrombin activity), or thrombin generation (high thrombin-antithrombin complex [TAT] and d-dimer concentrations).

High von Willebrand factor antigen concentration (vWF : Ag) was considered a marker of endothelial injury. Data were analyzed using nonparametric statistics.

Results: The 3 groups of cats with cardiac disease had higher median fibrinogen concentrations than did the healthy cats.

Criteria of hypercoagulability were found exclusively in cats with SEC-T (50%) and ATE (56%).

Hypercoagulability was not associated with left atrial size or congestive heart failure (CHF). ATE cats had significantly higher median vWF : Ag concentration than did the other groups.

Conclusions and Clinical Importance: Systemic hypercoagulability is evident in many cardiomyopathic cats, often without concurrent CHF or overt ATE.

Hypercoagulabilty may represent a risk factor for ATE.

High vWF : Ag in ATE cats was attributed to downstream endothelial injury from the occlusive thrombus.


Source: T. Stokol, et al (2008): Hypercoagulability in Cats with Cardiomyopathy. In: Journal of Veterinary Internal Medicine
Volume 22 Issue 3, Pages 546 - 552




Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Long-term compassionate use of oclacitinib in dogs with allergic skin disease
Oclacitinib is safe and effective for treating dogs with pruritus associated with allergic and atopic dermatitis, based on randomized clinical trials of up to 4 months duration. But unfortunately, allergic diseases currently can be managed but not cured, and in most cases a long-term therapy is indicated. This study assessed long-term safety, efficacy and quality of life of oclacitinib-treated dogs enrolled in a compassionate use programme including nearly 250 dogs.

  • Hypothyroidism and dilated cardiomyopathy in Doberman Pinschersmembers
  • Innovative emulsion of medium chain triglycerides against canine and feline periodontopathogensmembers
  • Retrobulbar and peribulbar regional techniques in catsmembers
  • Pulmonary hypertension in dogs naturally infected with Angiostrongylus vasorummembers
  • Intranasal versus intramuscular ketamine-midazolam in catsmembers
  • Imerslund-Gräsbeck syndrome in a young beaglemembers
  • A novel severity scoring system for dogs with heatstrokemembers
  • CT findings in cats with primary pulmonary neoplasiamembers
  • Multidetector CT to improve the detection of cardiac masses in dogs members
  • Pyothorax in dogs and cats - a clinical reviewmembers
  • Nasolacrimal canaliculocele with intranasal extension in a dogmembers
  • Drug combinations to inhibit rapidly growing mycobacteria isolates members


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2013 VetContact GmbH
    All rights reserved